ReviewThe Journal of physiology2020
Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology.
Review in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06297005 (The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes), which is not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes (ECHO) Study.
Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Pooled it
- Association of electronic cigarette use and risk of COPD: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2025Pooled it
- Review of quantitative and functional lung imaging evidence of vaping-related lung injury.Frontiers in medicine · 2024Pooled it
- Chronic health effects associated with electronic cigarette use: A systematic review.Frontiers in public health · 2022Pooled it
- Cardiopulmonary effects of combustible cigarettes and e-cigarettes in individuals with chronic obstructive pulmonary disease.Experimental and clinical psychopharmacology · 2026Trial
- Trial
- Acute analgesic effect of nicotine vaping using three experimental pain induction tasks: a randomized, placebo-controlled laboratory study.Psychopharmacology · 2025Trial
- Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial.Cardiovascular toxicology · 2023Trial
- Sub-acute dihydroxyacetone exposure alters mitochondria and induces cardiac strain.Toxicology reports · 2026Article
- E-cigarette vaping is associated with pro-fibrotic gene expression in kidney and liver tissues.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Global Burden of Non-Communicable Diseases from E‑Cigarette Exposure: Trend Analysis and 2050 Projections.Environment & health (Washington, D.C.) · 2026Article
- Impact of e-cigarette vaping on the immune system across the body.Physiological reviews · 2026Review
- Associations Between Oral Health Related Outcomes and Electronic Cigarette Use in Young People: A Scoping Review.International journal of paediatric dentistry · 2026Article
- Vaping-Associated Pneumomediastinum: A Case Report.Cureus · 2026Article
- Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Cardiovascular Consequences of E-Cigarettes: A New Challenge for Cardiologists.Journal of clinical medicine · 2026Review
- Differentiating the Determinants of Ever Having Used a Vape Versus Use Frequency: A Hurdle Modelling Approach.International journal of behavioral medicine · 2026Article
- Investigating the exhaled lipid biomarkers among e-cigarette users compared to non-smokers.Lipids in health and disease · 2026Article
- Evaluation of molecular interactions of vaping juice components with ACE2 receptor.Scientific reports · 2026Article
- The Influence of Smoking on Respiratory Function in Medical Students at the University of Medicine, Pharmacy, Science and Technology of Târgu-Mureș.Biomedicines · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
E-cigarette aerosols are exceedingly different from conventional tobacco smoke, containing dozens of chemicals not found in cigarette smoke. It is highly likely that chronic use of e-cigarettes will induce pathological changes in both the heart and lungs. Here we review human and animal studies published to date and summarize the cardiopulmonary physiological changes caused by vaping. In terms of cardiac physiology, acute exposure to e-cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar to traditional cigarettes. Chronic exposure to e-cigarette aerosols using animal models caused increased arterial stiffness, vascular endothelial changes, increased angiogenesis, cardiorenal fibrosis and increased atherosclerotic plaque formation. Pulmonary physiology is also affected by e-cigarette aerosol inhalation, with increased airway reactivity, airway obstruction, inflammation and emphysema. Research thus far demonstrates that the heart and lung undergo numerous changes in response to e-cigarette use, and disease development will depend on how those changes combine with both environmental and genetic factors. E-cigarettes have been advertised as a healthy alternative to cigarette smoking, and users are under the impression that vaping of e-cigarettes is harmless, but these claims that e-cigarettes are safer and healthier are not based on evidence. Data from both humans and animal models are consistent in demonstrating that vaping of e-cigarettes causes health effects both similar to and disparate from those of cigarette smoking. Further work is needed to define the long-term cardiopulmonary effects of e-cigarette use in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.