Evidence map›Paper›PMID 32975814›Full record

SynthesisJournal of medical virology2021

Obesity a predictor of outcomes of COVID-19 hospitalized patients-A systematic review and meta-analysis.

Preeti Malik, Urvish Patel, Karan Patel, Mehwish Martin, Chail Shah, Deep Mehta, Faizan Ahmad Malik, Ashish Sharma

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  12. Upregulation of inflammatory genes and pathways links obesity to severe COVID-19.Biochimica et biophysica acta. Molecular basis of disease · 2024
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  16. Patient Perspectives on the COVID-19 Vaccine: A Pilot Survey Study of Patients in Endocrinology Clinics.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Preeti MalikDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0002-9427-0225
Urvish PatelDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.
Karan PatelMS(1), Cooper Medical School of Rowan University, New Jersey, USA.
Mehwish MartinDepartment of Internal Medicine, Baylor St. Luke's Medical Center, Houston, Texas, USA.
Chail ShahDepartment of Internal Medicine, Brooklyn Cancer Care, New York, New York, USA.
Deep MehtaDepartment of Clinical Research Program, Icahn School of Medicine at Mount Sinai, New York, USA.
Faizan Ahmad MalikDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Odessa, Texas, USA.
Ashish SharmaDepartment of Internal Medicine, Yuma Regional Medicine, Yuma, Arizona, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) pandemic is a global health crisis. Very few studies have reported association between obesity and severity of COVID-19. In this meta-analysis, we assessed the association of obesity and outcomes in COVID-19 hospitalized patients. Data from observational studies describing the obesity or body mass index and outcomes of COVID-19 hospitalized patients from December 1, 2019, to August 15, 2020, was extracted following PRISMA guidelines with a consensus of two independent reviewers. Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in-hospital mortality. The odds ratio (OR) and 95% confidence interval (95% CI) were obtained and forest plots were created using random-effects models. A total of 10 studies with 10,233 confirmed COVID-19 patients were included. The overall prevalence of obesity in our study was 33.9% (3473/10,233). In meta-analysis, COVID-19 patient with obesity had higher odds of poor outcomes compared with better outcomes with a pooled OR of 1.88 (95% CI: 1.25-2.80; p = 0.002), with 86% heterogeneity between studies (p < 0.00001). Our study suggests a significant association between obesity and COVID-19 severity and poor outcomes. Our results findings may have important suggestions for the clinical management and future research of obesity and COVID-19.

Indexed as

Hospital MortalityBody Mass IndexCOVID-19HospitalizationHumansIntensive Care UnitsObesityObservational Studies as TopicPrevalenceRespiration, Artificial2019-nCoVbody mass index (BMI)coronavirus diseaseCOVID-19mechanical ventilationmortalityobesitySARS-CoV-2severe acute respiratory syndrome

Identifiers

PMID32975814
PMCPMC7537321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.