Evidence map›Paper›PMID 32975655›Full record

ArticleBrain structure & function2020

EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.

Moritz Negwer, Karol Piera, Rick Hesen, Lukas Lütje, Lynn Aarts, Dirk Schubert, Nael Nadif Kasri

Open access · hybridAbstract read
In one paragraph

Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Reprogramming of the epigenome in neurodevelopmental disorders.Critical reviews in biochemistry and molecular biology · 2022
    Review
  9. Review
  10. The Parvalbumin Hypothesis of Autism Spectrum Disorder.Frontiers in cellular neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Moritz NegwerDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Karol PieraDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Rick HesenDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Lukas LütjeDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Lynn AartsDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Dirk SchubertDepartment of Cognitive Neuroscience, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, 6500 HB, Nijmegen, The Netherlands.
Nael Nadif KasriDepartment of Human Genetics, Radboudumc, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, The Netherlands. n.nadif@donders.ru.nl.ORCID http://orcid.org/0000-0002-7448-9289
Radboud University Nijmegen · NL

Funding

NWO 012.200.001
6 · The paper itself

Abstract

Mutations in the Euchromatic Histone Methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a rare form of intellectual disability (ID) with strong autistic traits and sensory processing deficits. Proper development of inhibitory interneurons is crucial for sensory function. Here we report a timeline of Parvalbumin-positive (PV

Indexed as

AnimalsAuditory CortexCerebral CortexFemaleGABAergic NeuronsHistone-Lysine N-MethyltransferaseInterneuronsMaleMice, Inbred C57BLMice, TransgenicParvalbuminsSomatosensory CortexVisual CortexGLP protein, mouseHistone-Lysine N-MethyltransferaseParvalbuminsAutism spectrum disorderCortical developmentCritical periodEHMT1Gabaergic synapseKleefstra syndromeParvalbumin-positive interneurons

Identifiers

PMID32975655
PMCPMC7674571
OpenAlexW3088860730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.