ArticlePediatric cardiology2021
Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study.
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Article in Pediatric cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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30citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Fontan Patients with a Systemic Left Ventricle Have Greater Exercise Capacity than those with a Systemic Right Ventricle: A Systematic Review and Meta-Analysis.Pediatric cardiology · 2026Pooled it
- Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients.American heart journal · 2025Trial
- Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial.Journal of the American Heart Association · 2025Trial
- Isosorbide DiNitrate Effect on Hemodynamic Profile, Liver Stiffness, and Exercise Tolerance in Fontan Circulation (The NEET Clinical Trial).Pediatric cardiology · 2024Trial
- The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation.The American journal of cardiology · 2024Trial
- The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis.Pediatric cardiology · 2023Trial
- Frequency and Progression of Lung Disease Patterns in Patients with Fontan and Tetralogy of Fallot.Pediatric cardiology · 2026Article
- Body Mass Index and Physical Activity Among U.S. Children with Congenital Heart Conditions.Pediatric cardiology · 2026Article
- What Limits Cardiorespiratory Fitness in Adolescents with Fontan Circulation: An Integrated Hemodynamic and Pulmonary Perspective.Pediatric cardiology · 2026Article
- Protocol for non-invasive assessment of skeletal muscle structure and function in adolescents with single ventricle heart disease: a cross-sectional, case-control study.Frontiers in cardiovascular medicine · 2026Article
- Predictive Role of Atrial Strain, Aortic Stiffness, and Muscle-Related Factors for Maximal and Submaximal Exercise Capacity in Fontan Patients.Pediatric cardiology · 2025Observational
- Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation.Pediatric cardiology · 2025Article
- In Vitro and In Silico Analysis of Entrainment Characterization in Injection Jet-Assisted Fontan Circulation.Bioengineering (Basel, Switzerland) · 2025Article
- The Cardiovascular Care of the Pediatric Athlete.Journal of the American College of Cardiology · 2025Review
- Fontan haemodynamics in adults with obesity compared with overweight and normal body mass index: a retrospective invasive exercise study.European journal of preventive cardiology · 2025Article
- Exercise testing in clinical context: Reference ranges for interpreting anaerobic threshold as an outcome for congenital heart disease patients.International journal of cardiology. Congenital heart disease · 2024Article
- Home-based long-term physical endurance and inspiratory muscle training in children and adults with Fontan circulation.Frontiers in cardiovascular medicine · 2024Article
- Pilot Project: Heart Chargers-A Successful Model for a Home-Based Physical Activity Program Utilizing Telemedicine for Fontan Patients.Pediatric cardiology · 2023Article
- Exercise Pathophysiology and Testing in Individuals With a Fontan Circulation.CJC pediatric and congenital heart disease · 2023Review
- Peak Work Rate Increases With Lower Extremity-Focused Exercise Training in Adolescents With Fontan Circulation.Journal of the American Heart Association · 2022Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 2 countries.
David J GoldbergDivision of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA. goldbergda@email.chop.edu.ORCID http://orcid.org/0000-0002-4194-2067
Victor ZakHealthcore, Watertown, MA, 02472, USA.
Brian W McCrindleThe Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada.
Hua NiHealthcore, Watertown, MA, 02472, USA.
Russell GongwerHealthcore, Watertown, MA, 02472, USA.
Jonathan RhodesChildren's Hospital Boston, Harvard Medical School, Boston, MA, 02115, USA.
Robert P GarofanoMorgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, 10032, USA.
Jonathan R KaltmanDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Linda M LambertPrimary Children's Hospital, University of Utah, Salt Lake City, UT, 84132, USA.
Lynn MahonyChildren's Health Dallas, University of Texas Southwestern Medical School, Dallas, TX, 75390, USA.
Renee MargossianChildren's Hospital Boston, Harvard Medical School, Boston, MA, 02115, USA.
Zebulon Z SpectorDuke University School of Medicine, Durham, NC, 27710, USA.
Richard V WilliamsPrimary Children's Hospital, University of Utah, Salt Lake City, UT, 84132, USA.
Andrew M AtzMedical University of South Carolina, Charleston, SC, 29425, USA.
Stephen M ParidonDivision of Cardiology, The Children's Hospital of Philadelphia, Perelman School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA, 19104, USA.
Pediatric Heart Network Investigators
Boston Children's Hospital · USChildren's Hospital of Philadelphia · USPrimary Children's Hospital · USDuke University · USMedical University of South Carolina · USMorgan Stanley Children's Hospital · USNational Heart Lung and Blood Institute · USThe University of Texas Southwestern Medical Center · USUniversity of Toronto · CA
Funding
Pediatric Heart network DCCU10HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2011 to 2016
$44.9MVentricular Volumes and Varability (VVV)U01HL068270 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI SLEEPER, LYNN A · 2001 to 2010
$40.3MMIS-C Program: Data Coordinating Center for the Pediatric Heart Network MIS-C ProgramU24HL135691 · NHLBI · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MILLER, JULIE ELAINE, TRACHTENBERG, FELICIA LYNN · 2017 to 2024
$37.9MSidenafil Impacts Exercise Performance in Adolescent Survivors of the FontanU10HL109818 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI GAYNOR, JAMES WILLIAM, PARIDON, STEPHEN · 2011 to 2015
$2.7MRandomized Trial of Nonflouroscopic Technologies in Pediatric SVT AblationU10HL109816 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., TRIEDMAN, JOHN K · 2011 to 2015
$2.6MPediatric Heart Network Prairieland ConsortiumU10HL109673 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CNOTA, JAMES, PAYNE, RONALD MARK · 2011 to 2015
$2.3MPediatric Heart Network Regents of the University of MichiganU10HL109737 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDBERG, CAREN S, OHYE, RICHARD G · 2011 to 2015
$2.3MPediatric Heart Network University of UtahU10HL109743 · NHLBI · UNIVERSITY OF UTAH · PI MINICH, L. LUANN, WILLIAMS, RICHARD VINCENT · 2011 to 2015
$2.2MPediatric Heart Network Medical University of South CarolinaU10HL109778 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ATZ, ANDREW M, GRAHAM, ERIC M. · 2011 to 2015
$2.2MBaylor/Texas Children's Hospital Pediatric Heart NetworkU10HL109741 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI ANDROPOULOS, DEAN B., FRASER, CHARLES D. · 2011 to 2015
$2.1MPediatric Heart Network Emory UniversityU10HL109781 · NHLBI · EMORY UNIVERSITY · PI BORDER, WILLIAM, MAHLE, WILLIAM T · 2011 to 2015
$1.7MPediatric Heart Network - The Hospital for Sick Children, TorontoU10HL109777 · NHLBI · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI MCCRINDLE, BRIAN W, MITAL, SEEMA · 2011 to 2015
$1.6MNational Heart, Lung, and Blood Institute (US) U01 HL109778National Heart, Lung, and Blood Institute (US) U01 HL109816NHLBI NIH HHS U01 HL068270NHLBI NIH HHS U01 HL109673NHLBI NIH HHS U01 HL109737NHLBI NIH HHS U01 HL109741NHLBI NIH HHS U01 HL109743NHLBI NIH HHS U01 HL109777NHLBI NIH HHS U01 HL109781NHLBI NIH HHS U01 HL109818NHLBI NIH HHS U10 HL068270NHLBI NIH HHS U10 HL109673NHLBI NIH HHS U10 HL109737NHLBI NIH HHS U10 HL109741NHLBI NIH HHS U10 HL109743NHLBI NIH HHS U10 HL109777NHLBI NIH HHS U10 HL109778NHLBI NIH HHS U10 HL109781NHLBI NIH HHS U10 HL109816NHLBI NIH HHS U10 HL109818NHLBI NIH HHS U24 HL135691
Abstract
Impaired exercise following Fontan is a surrogate of morbidity. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Ramp cycle ergometry was re-performed in consented participants who had originally participated in the Pediatric Heart Network's Fontan cross-sectional study. Annualized change was evaluated at maximal and submaximal exercise. Associations between these outcomes and patient characteristics were analyzed. There were 336 participants in Fontan 3, mean age 23.2 years. Paired measurements of peak oxygen consumption (peak VO
Indexed as
Exercise ToleranceAdolescentAdultCross-Sectional StudiesExercise TestFemaleFollow-Up StudiesFontan ProcedureHeart Defects, CongenitalHeart VentriclesHumansMaleOxygen ConsumptionRetrospective StudiesYoung AdultCongenital heart diseaseExercise physiologyFontan
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