ReviewAdvances in nutrition (Bethesda, Md.)2021
Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link?
Review in Advances in nutrition (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 6 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Effect of vitamin D supplementation on clinical outcomes in adult patients with COVID-19: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.Pharmacology research & perspectives · 2024Pooled it
- Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2024Pooled it
- Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis.American journal of obstetrics and gynecology · 2023Pooled it
- Obesity and COVID-19. A necessary position statement.Endocrinologia, diabetes y nutricion · 2021Guideline
- Prevalence and outcomes of malnutrition among hospitalized COVID-19 patients: A systematic review and meta-analysis.Clinical nutrition ESPEN · 2021Pooled it
- Obesity and COVID-19. A necessary position statement.Endocrinologia, diabetes y nutricion · 2021Guideline
- Trial
- Use of a Humanized Anti-CD6 Monoclonal Antibody (Itolizumab) in Elderly Patients with Moderate COVID-19.Gerontology · 2020Trial
- Characteristics of Gut Microbiota in Patients with Severe Pneumonia and its Potential Clinical Relevance.Polish journal of microbiology · 2026Article
- Potential predictors of COVID-19 disease infection and severity in Egypt.Scientific reports · 2026Article
- Role of nutrition in diabetes mellitus and infections.World journal of clinical cases · 2025Article
- Perceptions of respiratory tract infections and their implications for disease prevention practices among older adults in Mysuru, India.PLOS global public health · 2025Article
- Impact of dietary patterns on body weight in girls with central precocious puberty treated with leuprolide during the COVID-19 pandemic.Frontiers in pediatrics · 2025Article
- Global, regional, and national burden of nutritional deficiencies spanning from 1990 to 2021, with a focus on the impacts observed during the COVID-19 pandemic.Frontiers in nutrition · 2025Article
- Assessing the Impact of Frailty on Infection Risk in Older Adults: Prospective Observational Cohort Study.JMIR public health and surveillance · 2024Observational
- Impact of Nutritional Status on COVID-19-Induced Olfactory Dysfunction.The Laryngoscope · 2024Article
- Adverse Events of COVID-19 Vaccines in the United States: Temporal and Spatial Analysis.JMIR public health and surveillance · 2024Article
- Nutritional and Inflammatory Markers Associated with SARS-CoV-2 Infection in the Elderly.International journal of molecular sciences · 2024Article
- Nutritional risk and functionality of children and adolescents hospitalized with COVID-19.European journal of pediatrics · 2024Article
- Potential Laboratory Markers in COVID-19 Patients with Gastrointestinal Impairments as Prognosticators of the Disease Severity.Tanaffos · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) is an emerging disease that has reached pandemic status by rapidly spreading worldwide. Elderly individuals and patients with comorbidities such as obesity, diabetes, and hypertension show a higher risk of hospitalization, severe disease, and mortality by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These patients frequently show exacerbated secretion of proinflammatory cytokines associated with an overreaction of the immune system, the so-called cytokine storm. Host nutritional status plays a pivotal role in the outcome of a variety of different infectious diseases. It is known that the immune system is highly affected by malnutrition, leading to decreased immune responses with consequent augmented risk of infection and disease severity. Body composition, especially low lean mass and high adiposity, has consistently been linked to worsened prognosis in many different diseases. In this review, evidence concerning the impact of nutritional status on viral infection outcomes is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.