ArticleJournal of oral & facial pain and headache2020
Experimental Pain Sensitivity in Subjects with Temporomandibular Disorders and Multiple Other Chronic Pain Conditions: The OPPERA Prospective Cohort Study.
Article in Journal of oral & facial pain and headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Improving well-being for individuals with persistent pain after surgery for breast cancer, lobular carcinoma in situ, or ductal carcinoma in situ: A randomized clinical trial.Contemporary clinical trials · 2022Trial
- Pain modulation profiles in temporomandibular disorders with migraine and fibromyalgia.Journal of oral & facial pain and headache · 2026Article
- Association Between Discordance of Disease Activity Indices and Quantitative Sensory Testing Measures of Nociplastic Pain in Patients With Rheumatoid Arthritis.Arthritis care & research · 2026Article
- Reduced trapezius pressure pain threshold in fibromyalgia and opioid use.The journal of pain · 2025Article
- Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study.Pain reports · 2024Article
- The normative values of pain thresholds in healthy Taiwanese.Brain and behavior · 2024Article
- Profiling migraine patients according to clinical and psychophysical characteristics: clinical validity of distinct migraine clusters.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Observational
- An Update on Temporomandibular Disorders (TMDs) and Headache.Current neurology and neuroscience reports · 2023Review
- Generalized Extension of Referred Trigeminal Pain due to Greater Occipital Nerve Entrapment.Case reports in neurological medicine · 2023Article
- Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.The Japanese dental science review · 2022Review
- Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions.Prostaglandins, leukotrienes, and essential fatty acids · 2022Article
- Ipsilateral Limb Extension of Referred Trigeminal Facial Pain due to Greater Occipital Nerve Entrapment: A Case Report.Case reports in neurological medicine · 2022Article
- Article
- Chronic Orofacial Pain: Models, Mechanisms, and Genetic and Related Environmental Influences.International journal of molecular sciences · 2021Review
- Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsTo investigate associations between experimental pain sensitivity and five chronic pain conditions among 655 participants in the OPPERA study.
methodsQuantitative sensory tests were used to measure sensitivity to three modalities of nociception: blunt pressure pain, mechanical pinprick pain, and thermal heat pain. Participants were also classified according to the presence or absence of five chronic pain conditions: temporomandibular disorders, headache, low back pain, irritable bowel syndrome, and fibromyalgia.
resultsUnivariate analyses found each modality to be significantly associated with at least one pain condition, most consistently for pressure pain sensitivity (8 of 15 instances) and least consistently for heat pain sensitivity (5 of 35 instances). Yet, multivariable analyses that evaluated the independent contributions of all five pain conditions found few significant associations (12 of 75 instances). Instead, pain sensitivity consistently varied according to the total number of pain conditions a person experienced, implying that the combination of pain conditions influences each nociceptive modality.
conclusionWhen evaluating nociceptive sensitivity in a chronic pain patient, comorbid pain conditions should be considered, as the more salient feature underlying sensitivity is likely the number rather than the type(s) of pain conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.