Evidence map›Paper›PMID 32975517›Full record

ArticleeLife2020

A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in

Jennifer D Cohen, Alessandro P Sparacio, Alexandra C Belfi, Rachel Forman-Rubinsky, David H Hall, Hannah Maul-Newby, Alison R Frand, Meera V Sundaram

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 67 citations in OpenAlex.

  1. Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. A Lipocalin and a Hedgehog-related protein are partners in thebioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Apical spectrin organizes cortical actin filament bundles to patternbioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. MLT-11 is necessary forbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Evaluation of Serum Supplementation on the Development ofInternational journal of molecular sciences · 2025
    Article
  15. Animal septins contain functional transmembrane domains.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Morphologically defined substages of tail morphogenesis in C. elegans males.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jennifer D CohenDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Alessandro P SparacioDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Alexandra C BelfiDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Rachel Forman-RubinskyDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0001-8459-9820
Hannah Maul-NewbyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0003-2187-7891
Alison R FrandDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-5972-989X
Meera V SundaramDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID 0000-0002-2940-8750
University of Pennsylvania · USUniversity of California, Los Angeles · USAlbert Einstein College of Medicine · US

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Penn Dermatology Research Training ProgramT32AR007465 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice, David Joel Margolis · 1986 to 2026
$9.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
CENTER FOR CAENORHABDITIS ELGANS ANATOMYR24RR012596 · NCRR · YESHIVA UNIVERSITY · PI HALL, DAVID H. · 1998 to 2011
$8.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Ras Signaling and Tubulogenesis in the C. elegans Excretory (renal) SystemR01GM058540 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNDARAM, MEERA · 2000 to 2019
$5.3M
Building and shaping the apical extracellular matrixR35GM136315 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Meera Sundaram · 2020 to 2026
$4.7M
Lipocalin-dependent glycocalyx organization and tube protectionR01GM125959 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SUNDARAM, MEERA · 2018 to 2019
$634k
NCRR NIH HHS R24 RR012596NIAMS NIH HHS T32 AR007465NIGMS NIH HHS R01 GM058540NIGMS NIH HHS R01 GM125959NIGMS NIH HHS R35 GM136315NIGMS NIH HHS T32 GM008216NIH HHS P40 OD010440NIH HHS R24 OD010943
6 · The paper itself

Abstract

Biological tubes must develop and maintain their proper diameter to transport materials efficiently. These tubes are molded and protected in part by apical extracellular matrices (aECMs) that line their lumens. Despite their importance, aECMs are difficult to image in vivo and therefore poorly understood. The

Indexed as

OrganogenesisAnimalsCaenorhabditis elegansEmbryo, NonmammalianExtracellular MatrixFemaleGlycoproteinsVulvaGlycoproteinsC. elegansdevelopmental biologyextracellular matrixlumenvulva

Identifiers

PMID32975517
PMCPMC7544507
OpenAlexW3087920740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.