Evidence map›Paper›PMID 32975498›Full record

ArticleToxicologic pathology2020

Ozone Reacts With Carbon Black to Produce a Fulvic Acid-Like Substance and Increase an Inflammatory Effect.

Andrew J Ghio, David H Gonzalez, Suzanne E Paulson, Joleen M Soukup, Lisa A Dailey, Michael C Madden, Beth Mahler, Susan A Elmore, Mette C Schladweiler, Urmila P Kodavanti

Open access · greenAbstract read
In one paragraph

Article in Toxicologic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Pollution, Inflammation, and Vaccines: A Complex Crosstalk.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Andrew J Ghio138030US Environmental Protection Agency, Research Triangle Park, NC, USA.ORCID 0000-0003-0502-6448
David H GonzalezAtmospheric and Oceanic Sciences, 8783University of California at Los Angeles, Los Angeles, CA, USA.
Suzanne E PaulsonAtmospheric and Oceanic Sciences, 8783University of California at Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0855-7615
Joleen M Soukup138030US Environmental Protection Agency, Research Triangle Park, NC, USA.
Lisa A Dailey138030US Environmental Protection Agency, Research Triangle Park, NC, USA.
Michael C Madden138030US Environmental Protection Agency, Research Triangle Park, NC, USA.
Beth MahlerExperimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA.
Susan A ElmoreNational Toxicology Program, 6857National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0002-1680-9176
Mette C Schladweiler138030US Environmental Protection Agency, Research Triangle Park, NC, USA.
Urmila P Kodavanti138030US Environmental Protection Agency, Research Triangle Park, NC, USA.ORCID 0000-0001-6333-1024
Environmental Protection Agency · USUniversity of California, Los Angeles · USExperimental Pathology Laboratories · USNational Institute of Environmental Health Sciences · US

Funding

Toxicologic Pathology Evaluations for the National Toxicology ProgramZIAES103319 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MALARKEY, DAVID · 2016 to 2019
$25.2M
Toxicologic Pathology Evaluations for the Division of the National Toxicology ProgramZICES103319 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CESTA, MARK · 2020 to 2021
$12.3M
Mouse Embryo Phenotyping CoreZICES103329 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SILLS, ROBERT · 2018 to 2021
$5.2M
Intramural NIH HHS Z99 ES999999Intramural NIH HHS ZIA ES103319Intramural NIH HHS ZIC ES103329
6 · The paper itself

Abstract

Exposure to ambient ozone has been associated with increased human mortality. Ozone exposure can introduce oxygen-containing functional groups in particulate matter (PM) effecting a greater capacity of the particle for metal complexation and inflammatory effect. We tested the postulate that (1) a fulvic acid-like substance can be produced through a reaction of a carbonaceous particle with high concentrations of ozone and (2) such a fulvic acid-like substance included in the PM can initiate inflammatory effects following exposure of respiratory epithelial (BEAS-2B) cells and an animal model (male Wistar Kyoto rats). Carbon black (CB) was exposed for 72 hours to either filtered air (CB-Air) or approximately 100 ppm ozone (CB-O

Indexed as

Air PollutantsOzoneAnimalsBenzopyransHumansMaleParticulate MatterRatsSootAir PollutantsBenzopyransfulvic acidOzoneParticulate MatterSootair pollutioncarbon blackfulvic acidfulvic acid-like substanceinflammationironlung diseasesozonerats

Identifiers

PMID32975498
PMCPMC7810358
OpenAlexW3087949705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.