Evidence map›Paper›PMID 32975231›Full record

ArticleJournal of biosciences2020

Differential transcriptome analysis in HPV-positive and HPV-negative cervical cancer cells through CRISPR knockout of miR-214.

Prakriti Sen, Pooja Ganguly, Kirti K Kulkarni, Roli Budhwar, Niladri Ganguly

Abstract read
PubMed
In one paragraph

Article in Journal of biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Prakriti SenCancer Biology Lab, School of Biotechnology, KIIT University, Bhubaneswar, India.
Pooja Ganguly
Kirti K Kulkarni
Roli Budhwar
Niladri Ganguly
KIIT University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study we have investigated the effects of a tumour suppressor microRNA, miR-214, on gene expression in HPV-positive (CaSki) and HPV-negative cervical cancer cells (C33A) by RNA sequencing using next generation sequencing. The HPV-positive and HPV-negative cervical cancer cells were either miR-214- knocked-out or miR-214-overexpressed. Gene expression analysis showed that a total of 904 genes were upregulated and 365 genes were downregulated between HPV-positive and HPV-negative cervical cancer cells with a fold change of +/- 2. Furthermore, 11 differentially expressed and relevant genes

Indexed as

TranscriptomeAmino Acid OxidoreductasesCD24 AntigenCell Cycle ProteinsCell Line, TumorCRISPR-Cas SystemsCytochrome P-450 CYP1B1FemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansHyaluronan ReceptorsIntracellular Signaling Peptides and ProteinsMicroRNAsMismatch Repair Endonuclease PMS2Amino Acid OxidoreductasesCD24 AntigenCD24 protein, humanCD44 protein, humanCell Cycle ProteinsCYP1B1 protein, humanCytochrome P-450 CYP1B1Hyaluronan ReceptorsIntracellular Signaling Peptides and ProteinsLATS1 protein, humanLOXL2 protein, humanMET protein, humanMicroRNAsMIRN214 microRNA, humanMismatch Repair Endonuclease PMS2Neoplasm ProteinsN-myc Downstream-Regulated Gene 1 ProteinPMS2 protein, humanProtein Serine-Threonine KinasesProto-Oncogene Proteins c-metRab25 protein, humanrab GTP-Binding ProteinsTNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID32975231
OpenAlexW3048864963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.