Evidence map›Paper›PMID 32974936›Full record

ArticleJournal of surgical oncology2021

Nodal characteristics associated with adverse prognosis in oral cavity cancer are linked to host immune status.

Cristina Valero, Daniella K Zanoni, Anjali Pillai, Bin Xu, Nora Katabi, Ronald A Ghossein, Ian Ganly, Luc G T Morris, Jatin P Shah, Richard J Wong and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Cristina ValeroDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-3397-2888
Daniella K ZanoniDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Anjali PillaiDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Bin XuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-4638-9835
Nora KatabiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ronald A GhosseinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ian GanlyDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Luc G T MorrisDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jatin P ShahDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0002-6444-6592
Richard J WongDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Snehal G PatelDepartment of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID https://orcid.org/0000-0001-9775-5132
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Fundación Alfonso Martín EscuderoNCI NIH HHS P30 CA008748NIH/NCI Cancer Center Support Grant P30 CA008748
6 · The paper itself

Abstract

BACKGROUND AND

objectiveNodal metastasis is one of the strongest predictors of outcomes in oral cavity squamous cell carcinomas (OSCC). The aim was to analyze the interplay of nodal characteristics in OSCC prognosis.

methodsIn this retrospective cohort study we included OSCC patients treated with primary surgery including neck dissection between 2005 and 2015 (n = 619). Disease-specific survival (DSS) was the primary endpoint. Optimal cutoffs were identified using recursive-partitioning analysis (RPA). A novel characteristic-metastatic focus-to-lymph node size ratio (MLR)-was introduced. We compared the American Joint Committee on Cancer, Eighth Edition (AJCC8) pN categories to a new categorization.

resultsPatients with higher neutrophil-to-lymphocyte ratio had more adverse nodal characteristics. All nodal characteristics were significant predictors of DSS in univariable analysis. In multivariable analysis, only number of positive nodes and MLR remained significant. An RPA including all nodal covariates confirmed the results. Compared with AJCC8, our RPA categorization had better hazard discrimination (0.681 vs. 0.598), but poorer balance value (0.783 vs. 0.708).

conclusionPatients with higher neutrophil-to-lymphocyte ratio had more adverse nodal characteristics. Total number of metastatic lymph nodes is the strongest predictor of outcomes in OSCC. MLR is a more powerful predictor than metastatic lymph node size or metastatic focus size alone.

Indexed as

AgedCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansLymphatic MetastasisLymph NodesMaleMiddle AgedMouth NeoplasmsNeck DissectionNeoplasm StagingRetrospective StudiesSurvival RateAmerican Joint Committee on Cancerlymph node metastasismetastatic focus-to-lymph node size ratiooral neoplasmsprognosis

Identifiers

PMID32974936
PMCPMC7770005
OpenAlexW3087909185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.