Evidence map›Paper›PMID 32974805›Full record

Observational studyJournal of assisted reproduction and genetics2020

Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure.

Mauro Cozzolino, Patricia Diaz-Gimeno, Antonio Pellicer, Nicolas Garrido

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05478616 (To Investigate the Expression of Endometrium During Window of Implantation Between Natural Cycles and Artificial Cycles), which is not on this map. Cited by 46 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478616 terminatednot on this mapstarted 2022, after this paper: background citation

To Investigate the Expression of Endometrium During Window of Implantation Between Natural Cycles and Artificial Cycles

TypeobservationalSponsorKaohsiung Veterans General Hospital.Ran2022 to 2023Enrolled3ConditionsUnrecognized Condition
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  14. A review of artificial intelligence applications in in vitro fertilization.Journal of assisted reproduction and genetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mauro CozzolinoIVIRMA, IVI Foundation, Avenida Fernando Abril Martorell, 106 - Torre A, Planta 1ª, 46026, Valencia, Spain. mauro.cozzolino@ivirma.com.ORCID http://orcid.org/0000-0002-5929-2357
Patricia Diaz-GimenoIVIRMA, IVI Foundation, Avenida Fernando Abril Martorell, 106 - Torre A, Planta 1ª, 46026, Valencia, Spain.
Antonio PellicerIVIRMA, IVI Foundation, Avenida Fernando Abril Martorell, 106 - Torre A, Planta 1ª, 46026, Valencia, Spain.
Nicolas GarridoIVIRMA, IVI Foundation, Avenida Fernando Abril Martorell, 106 - Torre A, Planta 1ª, 46026, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the clinical usefulness of the endometrial receptivity array (ERA) and the preimplantation genetic test for aneuploidy (PGT-A) in patients with severe and moderate recurrent implantation failure (RIF).

designA retrospective multicenter cohort study was conducted in patients who failed to achieve implantation following transfer of 3 or more or 5 or more embryos in at least three single embryo transfers; patients were classified as moderate or severe RIF, respectively. Patients with previous RIF were compared based on the testing they received: PGT-A, ERA, or PGT-A+ERA versus a control group with no testing. Mean implantation rate and ongoing pregnancy rates per embryo transfer were considered primary outcomes. Multiple logistic regression analysis was performed and adjusted ORs were calculated to control possible bias.

resultsOf the 2110 patients belonging to the moderate RIF group, those who underwent transfer of euploid embryos after PGT-A had a higher implantation rate than those who did not. Additionally, the PGT-A group had a significantly higher rate of ongoing pregnancy. The same outcomes measured for the 488 patients in the severe RIF group did not reveal any statistically significant improvements. The use of the ERA test did not appear to significantly improve outcomes in either group.

conclusionsPGT-A may be beneficial for patients with moderate recurrent implantation failure but not for severe cases. At its current level of development, ERA does not appear to be clinically useful for patients with RIF.

Indexed as

AneuploidyEmbryo ImplantationAdolescentAdultEmbryo TransferEndometriumFemaleFertilization in VitroGenetic TestingHumansInfertility, FemaleMiddle AgedPregnancyPregnancy OutcomePregnancy RatePreimplantation DiagnosisEmbryo transferEndometrial receptivityERA testImplantation rateInfertilityIVF cyclesOngoing pregnancy ratePGT-APregnancyRecurrent implantation failureWindow of implantation

Identifiers

PMID32974805
PMCPMC7714804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.