ArticleAnnals of biomedical engineering2021
Transcorneal Electrical Stimulation Reduces Neurodegenerative Process in a Mouse Model of Glaucoma.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Noninvasive electrical stimulation as a neuroprotective strategy in retinal diseases: a systematic review of preclinical studies.Journal of translational medicine · 2024Pooled it
- Spatiotemporal characteristics of visual cortical responses to transpalpebral electrical stimulation.iScience · 2026Article
- Modalities of vision restoration in optic neuropathies and retinal disease.Progress in retinal and eye research · 2026Review
- Population-scale analysis of frequency-dependent calcium dynamics in retinal ganglion cells under electric field stimulation.Scientific reports · 2026Article
- Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Optimizing stimulation parameters: transpalpebral and transbrain electrical stimulation for retinal protection in RCS rats.Frontiers in cell and developmental biology · 2026Article
- Comparison of Physiological Brain Responses Evoked by Visual and Electrical Stimulation.Investigative ophthalmology & visual science · 2025Article
- Mechanotransductive N-cadherin binding induces differentiation in human neural stem cells.Mechanobiology in medicine · 2025Article
- Transcorneal Electrical Stimulation Modulates Visual Pathway Function in Mice.Journal of neuroscience research · 2025Article
- Transcorneal electrical stimulation: impact on healthcare and future potential.Frontiers in cell and developmental biology · 2025Review
- Glaucomatous retinal ganglion cells: death and protection.International journal of ophthalmology · 2025Review
- Sustained Extracellular Electrical Stimulation Modulates the Permeability of Gap Junctions inInternational journal of molecular sciences · 2024Article
- Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration.Frontiers in molecular neuroscience · 2024Article
- Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects.The EPMA journal · 2023Article
- Glial cells as a promising therapeutic target of glaucoma: beyond the IOP.Frontiers in ophthalmology · 2023Review
- Advances in transcorneal electrical stimulation: From the eye to the brain.Frontiers in cellular neuroscience · 2023Review
- Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression.Cells · 2021Review
- Mechanisms of electrical stimulation in eye diseases: A narrative review.Advances in ophthalmology practice and researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Glaucoma is a neurodegenerative disease in which the retinal ganglion cell axons of the optic nerve degenerate concomitant with synaptic changes in the retina, leading finally to death of the retinal ganglion cells (RGCs). Electrical stimulation has been used to improve neural regeneration in a variety of systems, including in diseases of the retina. Therefore, the focus of this study was to investigate whether transcorneal electrical stimulation (TES) in the DBA2/J mouse model of glaucoma could improve retinal or optic nerve pathology and serve as a minimally invasive treatment option. Mice (10 months-old) received 21 sessions of TES over 8 weeks, after which we evaluated RGC number, axon number, and anterograde axonal transport using histology and immunohistochemistry. To gain insight into the mechanism of proposed protection, we also evaluated inflammation by quantifying CD3
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.