Evidence map›Paper›PMID 32974749›Full record

ArticleAmino acids2020

Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.

Rodrigo Manjarín, Claire Boutry-Regard, Agus Suryawan, Angela Canovas, Brian D Piccolo, Magdalena Maj, Mohammed Abo-Ismail, Hanh V Nguyen, Marta L Fiorotto, Teresa A Davis

Open access · greenAbstract read
In one paragraph

Article in Amino acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Amino acids and lean mass accretion in preterm neonates.Current opinion in clinical nutrition and metabolic care · 2026
    Review
  2. Review: Nutritional regulation of muscle growth in neonatal swine.Animal : an international journal of animal bioscience · 2023
    Review
  3. Amino Acids in Cell Signaling: Regulation and Function.Advances in experimental medicine and biology · 2021
    Article
  4. Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling.Advances in experimental medicine and biology · 2021
    Article
  5. Amino Acids in Autophagy: Regulation and Function.Advances in experimental medicine and biology · 2021
    Article
  6. Amino Acids and Their Metabolites for Improving Human Exercising Performance.Advances in experimental medicine and biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Rodrigo ManjarínChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA. rmanjari@calpoly.edu.
Claire Boutry-RegardChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA.
Agus SuryawanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA.
Angela CanovasOntario Agricultural College, University of Guelph, Guelph, Canada.
Brian D PiccoloArkansas Children's Nutrition Center, U.S. Department of Agriculture/Agricultural Research Service, Little Rock, AR, 72202, USA.
Magdalena MajBiological Sciences Department, California Polytechnic State University, San Luis Obispo, CA, 93407, USA.
Mohammed Abo-IsmailAnimal Science Department, California Polytechnic State University, 1 Grand Ave, San Luis Obispo, CA, 93407-0255, USA.
Hanh V NguyenChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA.
Marta L FiorottoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA.
Teresa A DavisChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, U.S. Department of Agriculture/Agricultural Research Service, Houston, TX, 77030, USA.
Agricultural Research Service · USChildren's Nutrition Research Center at Baylor College of Medicine · USCalifornia Polytechnic State University · USUniversity of Guelph · CA

Funding

REGULATION OF NEONATAL MUSCLE PROTEIN SYNTHESISR01HD085573 · NICHD · TEXAS A&M AGRILIFE RESEARCH · PI TERESA A DAVIS · 2016 to 2026
$4.7M
Regulation of Neonatal Muscle Protein SynthesisR01AR044474 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 1996 to 2012
$4.2M
DEVELOPMENTAL DETERMINANTS OF SKELETAL MUSCLE GROWTH POTENTIALR01AR046308 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI FIOROTTO, MARTA L · 2000 to 2011
$2.9M
Leucine Supplementation to Promote Lean Growth in Early LifeR01HD072891 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 2012 to 2015
$1.4M
Leucine and HMB Supplementation in Early Life to Promote Muscle Growth at the Expense of Adipose DepositionR01HD099080 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A, FIOROTTO, MARTA L · 2019 to 2021
$1.2M
DEVELOPMENTAL DETERMINANTS OF SKELETAL MUSCLE GROWTHR55AR046308 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI FIOROTTO, MARTA L · 1999 to 1999
–
Agricultural Research Institute, California State University 58982Agricultural Research Service 6250-510000-055National Institute of Child Health and Human Development HD-072891National Institute of Child Health and Human Development HD085573National Institute of Food and Agriculture 2013-67015-20438NIAMS NIH HHS AR-044474NIAMS NIH HHS AR-46308NIAMS NIH HHS R01 AR044474NIAMS NIH HHS R01 AR046308NIAMS NIH HHS R55 AR046308NICHD NIH HHS R01 HD072891NICHD NIH HHS R01 HD085573NICHD NIH HHS R01 HD099080
6 · The paper itself

Abstract

When neonatal pigs continuously fed formula are supplemented with leucine pulses, muscle protein synthesis and body weight gain are enhanced. To identify the responsible mechanisms, we combined plasma metabolomic analysis with transcriptome expression of the transcriptome and protein catabolic pathways in skeletal muscle. Piglets (n = 23, 7-day-old) were fed continuously a milk replacement formula via orogastric tube for 21 days with an additional parenteral infusion (800 μmol kg

Indexed as

Dietary SupplementsAnimalsAnimals, NewbornFemaleLeucineMetabolomeMuscle ProteinsMuscle, SkeletalMuscular AtrophyPhosphorylationSwineTranscriptomeLeucineMuscle ProteinsLeucineMetabolomicsOrogastric feedingProtein synthesisTranscriptomics

Identifiers

PMID32974749
PMCPMC8279413
OpenAlexW3088723602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.