Evidence map›Paper›PMID 32974728›Full record

ArticlePediatric nephrology (Berlin, Germany)2021

The current status of kidney transplantation in Nigerian children: still awaiting light at the end of the tunnel.

Felicia U Eke, Taiwo A Ladapo, Augustina N Okpere, Olalekan Olatise, Ifeoma Anochie, Tochi Uchenwa, Henrietta Okafor, Paul Ibitoye, Uchenna Ononiwu, Ademola Adebowale and 2 more

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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Paediatric nephrology in under-resourced areas.Pediatric nephrology (Berlin, Germany) · 2022
    Review
  8. Article
  9. Review
  10. Review
  11. Paediatric Nephrology in Africa.Current pediatrics reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Felicia U EkeUniversity of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria. fellyeke@yahoo.com.ORCID 0000-0002-4782-175X
Taiwo A LadapoLagos University Teaching Hospital, Lagos, Lagos State, Nigeria.
Augustina N OkpereUniversity of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
Olalekan OlatiseZenith Medical Centre, Abuja, Federal Capital Territory, Nigeria.
Ifeoma AnochieUniversity of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
Tochi UchenwaUniversity of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
Henrietta OkaforUniversity of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria.
Paul IbitoyeUsman Da Fodio University Teaching Hospital, Sokoto, Sokoto State, Nigeria.
Uchenna OnoniwuNational Hospital, Abuja, Federal Capital Territory, Nigeria.
Ademola AdebowaleUniversity College Hospital, Ibadan, Oyo State, Nigeria.
Rosamund AkuseAhmadu Bello University Teaching Hospital, Zaria, Nigeria.
Seyi OniyangiNational Hospital, Abuja, Federal Capital Territory, Nigeria.
University of Port Harcourt Teaching Hospital · NGNational Hospital Abuja · NGAhmadu Bello University Teaching Hospital · NGLagos University Teaching Hospital · NGUniversity College Hospital, Ibadan · NGUniversity of Nigeria Teaching Hospital · NGUsmanu Danfodiyo University Teaching Hospital, Sokoto · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKidney transplantation (KT) is the gold standard treatment for children with chronic kidney disease stage 5 (CKD5). It is easily accessible in well-resourced countries, but not in low/middle-income countries (LMICs). We present, a multicentre experience of paediatric KT of children domiciled in Nigeria. We aim to highlight the challenges and ethical dilemmas that children, their parents or guardians and health care staff face on a daily basis.

methodsA multicentre survey of Nigerian children who received KTs within or outside Nigeria from 1986 to 2019 was undertaken using a questionnaire emailed to all paediatric and adult consultants who are responsible for the care of children with kidney diseases in Nigeria. Demographic data, causes of CKD5, sources of funding, donor organs and graft and patient outcome were analysed. Using Kaplan-Meier survival analysis, we compared graft and patient survival.

resultsTwenty-two children, aged 4-18 years, received 23 KTs, of which 12 were performed in Nigeria. The male-to-female ratio was 3.4:1. Duration of pre-transplant haemodialysis was 4-48 months (median 7 months). Sixteen KTs were self-funded. State governments funded 3 philanthropists 4 KTs. Overall differences in graft and patient survival between the two groups, log rank test P = 0.68 and 0.40, respectively were not statistically significant.

conclusionsThe transplant access rate for Nigerian children is dismal at < 0.2%. Poor funding is a major challenge. There is an urgent need for the federal government to fund health care and particularly KTs. Graphical Abstract.

Indexed as

Kidney Failure, ChronicKidney TransplantationChildFemaleGraft RejectionGraft SurvivalHumansKaplan-Meier EstimateMaleNigeriaRenal DialysisRetrospective StudiesChallengesFundingKidney transplantationNigerian childrenTransplant tourism

Identifiers

PMID32974728
OpenAlexW3087875542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.