Evidence map›Paper›PMID 32974364›Full record

ReviewFrontiers in medicine2020

The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury.

Vikram Sabapathy, Rajkumar Venkatadri, Murat Dogan, Rahul Sharma

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. ST2 Signaling Regulates Innate Immune Responses in Kidney Injury.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Tilianin Reduces ApoptosisFrontiers in pharmacology · 2022
    Article
  6. Review
  7. Article
  8. The COVIDome Explorer Researcher Portal.medRxiv : the preprint server for health sciences · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vikram SabapathyDivision of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia, Charlottesville, VA, United States.
Rajkumar VenkatadriDivision of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia, Charlottesville, VA, United States.
Murat DoganDivision of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia, Charlottesville, VA, United States.
Rahul SharmaDivision of Nephrology, Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia, Charlottesville, VA, United States.
University of Virginia · US

Funding

The TREX1 Pathway in Autoimmune DiseaseR01AI116725 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PERRINO, FRED W · 2016 to 2020
$1.9M
Regulatory T Cells in Acute Kidney InjuryR01DK104963 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHARMA, RAHUL · 2016 to 2020
$1.8M
Targeting Treg for Therapy of Lupus GlomerulonephritisR01DK105833 · NIDDK · UNIVERSITY OF VIRGINIA · PI FU, SHU MAN, SHARMA, RAHUL · 2016 to 2019
$1.4M
Circulating Renal-Protective Mediators in Cardiac Surgery PatientsR21DK112105 · NIDDK · UNIVERSITY OF VIRGINIA · PI LYNCH, KEVIN R., ROSNER, MITCHELL H. · 2017 to 2018
$443k
NIAID NIH HHS R01 AI116725NIDDK NIH HHS R01 DK104963NIDDK NIH HHS R01 DK105833NIDDK NIH HHS R21 DK112105
6 · The paper itself

Abstract

Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain immune cells contributing to renal damage, whereas others offer protection and facilitate recovery. Alarmins are small molecules and proteins that include granulysins, high-mobility group box 1 protein, interleukin (IL)-1α, IL-16, IL-33, heat shock proteins, the Ca

Indexed as

AKIalarminsCytokinesDAMPIL-33inflammationregenerationT-regulatory cells

Identifiers

PMID32974364
PMCPMC7472534
OpenAlexW3081286785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.