Evidence map›Paper›PMID 32974319›Full record

ReviewFrontiers in bioengineering and biotechnology2020

Maturation of the Locomotor Circuitry in Children With Cerebral Palsy.

Germana Cappellini, Francesca Sylos-Labini, Arthur H Dewolf, Irina A Solopova, Daniela Morelli, Francesco Lacquaniti, Yury Ivanenko

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Neural Correlates of Mobility in Children with Cerebral Palsy: A Systematic Review.International journal of environmental research and public health · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Germana CappelliniLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Francesca Sylos-LabiniLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Arthur H DewolfCentre of Space Bio-medicine and Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Irina A SolopovaLaboratory of Neurobiology of Motor Control, Institute for Information Transmission Problems, Moscow, Russia.
Daniela MorelliDepartment of Pediatric Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
Francesco LacquanitiLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.
Yury IvanenkoLaboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first years of life represent an important phase of maturation of the central nervous system, processing of sensory information, posture control and acquisition of the locomotor function. Cerebral palsy (CP) is the most common group of motor disorders in childhood attributed to disturbances in the fetal or infant brain, frequently resulting in impaired gait. Here we will consider various findings about functional maturation of the locomotor output in early infancy, and how much the dysfunction of gait in children with CP can be related to spinal neuronal networks vs. supraspinal dysfunction. A better knowledge about pattern generation circuitries in infancy may improve our understanding of developmental motor disorders, highlighting the necessity for regulating the functional properties of abnormally developed neuronal locomotor networks as a target for early sensorimotor rehabilitation. Various clinical approaches and advances in biotechnology are also considered that might promote acquisition of the locomotor function in infants at risk for locomotor delays.

Indexed as

abnormal developmentcerebral palsyearly development of locomotionneuromuscular pattern generationrehabilitationspinal locomotor output

Identifiers

PMID32974319
PMCPMC7462003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.