Evidence map›Paper›PMID 32974204›Full record

ArticleFrontiers in oncology2020

Multiple Chromoanasynthesis in a Rare Case of Sporadic Renal Leiomyosarcoma: A Case Report.

Kirill Igorevich Anoshkin, Kristina Olegovna Karandasheva, Kristina Mikhaylovna Goryacheva, Denis Valer'yevich Pyankov, Philipp Aleksandrovich Koshkin, Tatiana Vladimirovna Pavlova, Alexandr Nikolaevich Bobin, Evgeniy Valer'yevich Shpot, Yaroslav Nikolayevich Chernov, Andrei Zinov'yevich Vinarov and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Chromoanasynthesis.Methods in molecular biology (Clifton, N.J.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kirill Igorevich AnoshkinResearch Centre for Medical Genetics, Moscow, Russia.
Kristina Olegovna KarandashevaResearch Centre for Medical Genetics, Moscow, Russia.
Kristina Mikhaylovna GoryachevaI.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Denis Valer'yevich PyankovGenomed Ltd., Moscow, Russia.
Philipp Aleksandrovich KoshkinGenomed Ltd., Moscow, Russia.
Tatiana Vladimirovna PavlovaN.N. Burdenko Main Military and Clinical Hospital, Moscow, Russia.
Alexandr Nikolaevich BobinN.N. Burdenko Main Military and Clinical Hospital, Moscow, Russia.
Evgeniy Valer'yevich ShpotI.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Yaroslav Nikolayevich ChernovI.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Andrei Zinov'yevich VinarovI.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Dmitry Vladimirovich ZaletaevI.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Sergei Ivanovich KutsevResearch Centre for Medical Genetics, Moscow, Russia.
Vladimir Viktorovich StrelnikovResearch Centre for Medical Genetics, Moscow, Russia.
Sechenov University · RUResearch Centre for Medical Genetics · RUBurdenko Neurosurgery Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the genetic profile of kidney giant leiomyosarcoma characterized by sequencing of 409 cancer related genes and chromosomal microarray analysis. Renal leiomyosarcomas are extremely rare neoplasms with aggressive behavior and poor survival prognosis. Most frequent somatic events in leiomyosarcomas are mutations in the TP53, RB1, ATRX, and PTEN genes, chromosomal instability (CIN) and chromoanagenesis. 67-year-old woman presented with a right kidney completely replaced by tumor. Immunohistochemical reaction on surgical material was positive to desmin and smooth muscle actin. Molecular genetic analysis revealed that tumor harbored monosomy of chromosomes 3 and 11, gain of Xp (ATRX) arm and three chromoanasynthesis regions (6q21-q27, 7p22.3-p12.1, and 12q13.11-q21.2), with MDM2 and CDK4 oncogenes copy number gains, whereas no copy number variations (CNVs) or tumor specific single nucleotide variants (SNVs) in TP53, RB1, and PTEN genes were present. We hypothesize that chromoanasynthesis in 12q13.11-q21.2 could be a trigger of observed CIN in this tumor.

Indexed as

chromoanagenesischromoanasynthesischromosomal instabilityleiomyosarcomaMDM2microarrayNGSrenal

Identifiers

PMID32974204
PMCPMC7466669
OpenAlexW3049988584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.