Evidence map›Paper›PMID 32974197›Full record

ArticleFrontiers in oncology2020

Comprehending Meningioma Signaling Cascades Using Multipronged Proteomics Approaches & Targeted Validation of Potential Markers.

Shuvolina Mukherjee, Deeptarup Biswas, Rucha Gadre, Pooja Jain, Nelofer Syed, Julianna Stylianou, Qingyu Zeng, Anita Mahadevan, Sridhar Epari, Prakash Shetty and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Shuvolina MukherjeeProteomics Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
Deeptarup BiswasProteomics Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
Rucha GadreProteomics Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
Pooja JainCentre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, United Kingdom.
Nelofer SyedDivision of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.
Julianna StylianouDivision of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.
Qingyu ZengDivision of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom.
Anita MahadevanDepartment of Neuropathology, Human Brain Tissue Repository (Brain Bank), NIMHANS, Bengaluru, India.
Sridhar EpariDepartment of Pathology, Tata Memorial Centre, Mumbai, India.
Prakash ShettyDepartment of Neurosurgery, Tata Memorial Centre, Mumbai, India.
Aliasgar MoiyadiDepartment of Neurosurgery, Tata Memorial Centre, Mumbai, India.
Graham Roy BallSchool of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.
Sanjeeva SrivastavaProteomics Lab, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai, India.
Imperial College London · GBIndian Institute of Technology Bombay · INTata Memorial Hospital · INNational Institute of Mental Health and Neurosciences · INNottingham Trent University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningiomas are one of the most prevalent primary brain tumors. Our study aims to obtain mechanistic insights of meningioma pathobiology using mass spectrometry-based label-free quantitative proteome analysis to identifying druggable targets and perturbed pathways for therapeutic intervention. Label-free based proteomics study was done from peptide samples of 21 patients and 8 non-tumor controls which were followed up with Phosphoproteomics to identify the kinases and phosphorylated components of the perturbed pathways.

Indexed as

Integrin Linked Kinase inhibitionIntegrin pathwaylabel-free proteomicsmeningioma tissuepatient-derived primary cell linePI3K-Akt pathwayRT2 PCR arrays

Identifiers

PMID32974197
PMCPMC7482667
OpenAlexW3081893258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.