ArticleTranslational vision science & technology2020
Revisiting the Drasdo Model: Implications for Structure-Function Analysis of the Macular Region.
Article in Translational vision science & technology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Point-to-Point Macular Structure-Function Relationships in Healthy and Glaucomatous Eyes Using OCT and Microperimetry.Journal of clinical medicine · 2026Article
- Perimetric Stimuli Undergoing Complete Spatial Summation Optimize the Detection of Retinal Ganglion Cell Density Gradients in Healthy Observers.Translational vision science & technology · 2025Article
- Predicting the Structure-Function Relationship in Glaucoma Using a Physiological Model.Investigative ophthalmology & visual science · 2025Article
- Photoreceptor Characteristics in Diabetic Retinopathy vs Controls Using Adaptive Optics Imaging: Systematic Review.Journal of vitreoretinal diseases · 2024Review
- A Practical Framework for the Integration of Structural Data Into Perimetric Examinations.Translational vision science & technology · 2024Article
- Characterisation of the normal human ganglion cell-inner plexiform layer using widefield optical coherence tomography.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
- MP-3 microperimeter in early primary open angle glaucoma with a new pattern.International journal of ophthalmology · 2024Article
- Spatial Summation in the Glaucomatous Macula: A Link With Retinal Ganglion Cell Damage.Investigative ophthalmology & visual science · 2023Article
- Spatiotemporal summation of perimetric stimuli in healthy observers.Journal of vision · 2023Article
- High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Examining the concordance of retinal ganglion cell counts generated using measures of structure and function.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022Article
- Letter to the Editor: Expected Improvement in Structure-Function Agreement With Macular Displacement Models.Translational vision science & technology · 2022Article
- Author Response: Expected Improvement in Structure-Function Agreement With Macular Displacement Models.Translational vision science & technology · 2022Article
- Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank.Investigative ophthalmology & visual science · 2022Article
- Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and OCT Imaging.Ophthalmology · 2022Article
- Elucidating macular structure-function correlations in glaucoma.Scientific reports · 2022Article
- Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness.Translational vision science & technology · 2022Article
- Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses.Translational vision science & technology · 2021Article
- Evidence for Structural and Functional Damage of the Inner Retina in Diabetes With No Diabetic Retinopathy.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Purpose: To provide a consistent implementation of a retinal ganglion cell (RGC) displacement model proposed by Drasdo et al. for macular structure-function analysis, customizable by axial length (AL). Methods: The effect of axial length on the shape of the inner retina was measured on 235 optical coherence tomography (OCT) scans from healthy eyes, to provide evidence for geometric scaling of structures with eye size. Following this assumption, we applied the Drasdo model to map perimetric stimuli on the radially displaced RGCs using two different methods: Method 1 only displaced the center of the stimuli; Method 2 applied the displacement to every point on the edge of the stimuli. We compared the accuracy of the two methods by calculating, for each stimulus, the number of expected RGC receptive fields and the number RGCs calculated from the histology map, expected to be equivalent. The same calculation was repeated on RGC density maps derived from 28 OCT scans from 28 young healthy subjects (age < 40 years) to confirm our results on clinically available measurements. Results: The size of the retinal structures significantly increased with AL ( Conclusions: The Drasdo model can effectively account for AL assuming geometric scaling. Method 2 should be used for structure-function analyses. Translational Relevance: We developed a free web App in Shiny R to make our results available for researchers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.