ReviewSAGE open medicine2020
Targeted muscle reinnervation for the management of pain in the setting of major limb amputation.
Review in SAGE open medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05554900 (The Efficacy, Safety and Prognosis of Preventive Regenerative Peripheral Nerve Interface), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy, Safety and Prognosis of Preventive Regenerative Peripheral Nerve Interface(RPNI) Reconstruction in Amputees: Study Protocol for a Cohort Study
Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Primary 3-Month Outcomes of a Double-Blind Randomized Prospective Study (The QUEST Study) Assessing Effectiveness and Safety of Novel High-Frequency Electric Nerve Block System for Treatment of Post-Amputation Pain.Journal of pain research · 2024Trial
- Cost and Complication Profile of Targeted Muscle Reinnervation.Plastic and reconstructive surgery. Global open · 2026Article
- Outcomes Following Targeted Muscle Reinnervation in Pediatric Amputations: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026Article
- Vibrotactile Stimulation in Lower Extremity Amputation Patients Using a Noninvasive Vibration Device: A Pilot Study.Plastic and reconstructive surgery. Global open · 2025Article
- Targeted Muscle Reinnervation-an Up-to-Date Review: Evidence, Indications, and Technique.Archives of plastic surgery · 2025Article
- Multidisciplinary protocols are an important part of enhanced recovery after major lower extremity amputation.Frontiers in surgery · 2025Review
- Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Targeted muscle reinnervation in upper extremity amputations.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Review
- Peripheral Nerve Blocks as a Predictor of Nerve Reconstruction Success After Major Limb Amputation.Cureus · 2024Article
- Similar rates of reoperation for neuroma after transtibial amputations with and without targeted muscle reinnervation.OTA international : the open access journal of orthopaedic trauma · 2024Article
- TMR for Peripheral Sensory Nerve Neuroma around the Wrist Utilizing the Distal Anterior Interosseous Nerve.Plastic and reconstructive surgery. Global open · 2024Article
- Demystifying Targeted Muscle Reinnervation: A Systematic Review of Nerve Transfers for the Lower Extremity.Plastic and reconstructive surgery. Global open · 2023Article
- Osseointegration for Lower-Extremity Amputees: Operative Considerations from the Plastic Surgeon's Perspective.JBJS reviews · 2022Article
- Pericyte‑derived extracellular vesicles‑mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection.International journal of molecular medicine · 2022Article
- An Algorithm Approach to Phantom Limb Pain.Journal of pain research · 2022Review
- The Need to Work Arm in Arm: Calling for Collaboration in Delivering Neuroprosthetic Limb Replacements.Frontiers in neurorobotics · 2021Review
- Soft-Tissue Contouring and Nerve Management During Lower-Limb Osseointegration Surgery.JBJS essential surgical techniquesArticle
- Stump-plasty: An Operation Born of Necessity in Gaza.Strategies in trauma and limb reconstructionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The life altering nature of major limb amputations may be further complicated by neuroma formation in up to 60% of the estimated 2 million major limb amputees in the United States. This can be a source of pain and functional limitation of the residual limb. Pain associated with neuromas may limit prosthetic limb use, require reoperation, lead to opioid dependence, and dramatically reduce quality of life. A number of management options have been described including excision alone, excision with repair, excision with transposition, and targeted muscle reinnervation. Targeted muscle reinnervation has been shown to reduce phantom limb and neuroma pain for patients with upper and lower extremity amputations. It may be performed at the time of initial amputation to prevent pain development or secondarily for the treatment of established pain. Encouraging outcomes have been reported, and targeted muscle reinnervation is emerging as a leading surgical technique for pain prevention in patients undergoing major limb amputations and pain management in patients with pre-existing amputations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.