Evidence map›Paper›PMID 32973872›Full record

ReviewFrontiers in genetics2020

Understanding the Interplay Between Health Disparities and Epigenomics.

Viviana J Mancilla, Noah C Peeri, Talisa Silzer, Riyaz Basha, Martha Felini, Harlan P Jones, Nicole Phillips, Meng-Hua Tao, Srikantha Thyagarajan, Jamboor K Vishwanatha

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 63 citations in OpenAlex.

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  15. HowJournal of clinical and translational science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Viviana J MancillaDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Noah C PeeriDepartment of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, United States.
Talisa SilzerDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Riyaz BashaDepartment of Pediatrics, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
Martha FeliniDepartment of Pediatrics, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
Harlan P JonesDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Nicole PhillipsDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Meng-Hua TaoDepartment of Biostatistics and Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, United States.
Srikantha ThyagarajanDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
Jamboor K VishwanathaDepartment of Microbiology, Immunology and Genetics, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, United States.
University of North Texas Health Science Center · USUniversity of North Texas · US

Funding

Texas Minority Health, Research and Outreach (MiHERO)S21MD012472 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JAMBOOR K. VISHWANATHA · 2017 to 2026
$18.0M
Texas Center for Minority Health, Education, Research and OutreachU54MD006882 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI VISHWANATHA, JAMBOOR K. · 2017 to 2022
$6.0M
Triple Negative Breast Cancer: Novel Biomarkers and Therapeutic StrategiesP20MD006882 · NIMHD · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI VISHWANATHA, JAMBOOR K. · 2012 to 2016
$5.8M
UNTHSC Summer Multicultural Advanced Research Training Program "SMART"R25HL007786 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JONES, HARLAN PIERRE · 2008 to 2023
$2.1M
UNT Health Science Center IMSDR25GM125587 · NIGMS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JONES, HARLAN PIERRE · 2018 to 2022
$1.4M
NHLBI NIH HHS R25 HL007786NIGMS NIH HHS R25 GM125587NIMHD NIH HHS P20 MD006882NIMHD NIH HHS S21 MD012472NIMHD NIH HHS U54 MD006882
6 · The paper itself

Abstract

Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.

Indexed as

cancerchronic diseaseepigeneticshealth disparitiessocial determinants of health

Identifiers

PMID32973872
PMCPMC7468461
OpenAlexW3081122716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.