Evidence map›Paper›PMID 32973804›Full record

ArticleFrontiers in immunology2020

Human Regulatory Dendritic Cells Develop From Monocytes in Response to Signals From Regulatory and Helper T Cells.

Xiangyue Zhang, Pingping Zheng, Tyler R Prestwood, Hong Zhang, Yaron Carmi, Lorna L Tolentino, Nancy Wu, Okmi Choi, Daniel A Winer, Samuel Strober and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention.Apoptosis : an international journal on programmed cell death · 2026
    Review
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  15. Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection.Matrix biology : journal of the International Society for Matrix Biology · 2021
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Xiangyue ZhangDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Pingping ZhengBone Marrow Transplantation, Stanford University School of Medicine, Palo Alto, CA, United States.
Tyler R PrestwoodDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Hong ZhangDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Yaron CarmiDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Lorna L TolentinoDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Nancy WuDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Okmi ChoiDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Daniel A WinerBuck Institute for Research on Aging, Novato, CA, United States.
Samuel StroberDivision of Immunology and Rheumatology, Department of Medicine, Stanford University of Medicine, Stanford, CA, United States.
Eun-Suk KangDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea.
Michael N AlonsoDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Edgar G EnglemanDepartment of Pathology, Blood Center, Stanford University School of Medicine, Palo Alto, CA, United States.
Stanford University · USStanford Blood Center · USBuck Institute for Research on Aging · USSamsung Medical Center · KR

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
Targeting Dectin-2 on Tumor-associated Macrophages for the Treatment of CancerR01CA222969 · NCI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2018 to 2022
$2.1M
Role of Dendritic Cells in Mixed Chimerism and ToleranceR01AI118884 · NIAID · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G., STROBER, SAMUEL · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA222969NHLBI NIH HHS P01 HL075462NIAID NIH HHS R01 AI118884
6 · The paper itself

Abstract

Dendritic cells (DCs) are powerful antigen presenting cells, derived from bone marrow progenitors (cDCs) and monocytes (moDCs), that can shape the immune response by priming either proinflammatory or tolerogenic immune effector cells. The cellular mechanisms responsible for the generation of DCs that will prime a proinflammatory or tolerogenic response are poorly understood. Here we describe a novel mechanism by which tolerogenic DCs are formed from monocytes. When human monocytes were cultured with CD4

Indexed as

Cell CommunicationSignal TransductionBiomarkersCD4-Positive T-LymphocytesCell DifferentiationColonic NeoplasmsComputational BiologyDendritic CellsGene Expression ProfilingHumansImmunomodulationImmunophenotypingMonocytesT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsTranscriptomeBiomarkersDCRegDCsmonocytesThTregs

Identifiers

PMID32973804
PMCPMC7461788
OpenAlexW3060853466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.