Evidence map›Paper›PMID 32973799›Full record

ArticleFrontiers in immunology2020

Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice.

Abdelilah Majdoubi, Jun Seong Lee, Osama A Kishta, Mohammad Balood, Mohamed Abdelwafi Moulefera, Satoshi Ishido, Sébastien Talbot, Cheolho Cheong, Thierry Alquier, Jacques Thibodeau

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Abdelilah MajdoubiDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Jun Seong LeeDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Osama A KishtaDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Mohammad BaloodDépartement de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada.
Mohamed Abdelwafi MouleferaDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Satoshi IshidoDepartment of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan.
Sébastien TalbotDépartement de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada.
Cheolho CheongInstitut de Recherches Cliniques de Montréal (IRCM), Montreal, QC, Canada.
Thierry AlquierCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal Diabetes Research Center, and Département de Médicine, Université de Montréal, Montreal, QC, Canada.
Jacques ThibodeauDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Université de Montréal · CACentre Hospitalier de l’Université de Montréal · CAHyogo Medical University · JPMontreal Clinical Research Institute · CA

Funding

CIHR MOP1368802
6 · The paper itself

Abstract

Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. However, the mechanisms that trigger the underlying adipose tissues inflammation are not completely understood. Here, we show that the E3 ubiquitin ligase March1 controls the phenotypic and functional properties of CD8

Indexed as

Immunologic MemoryInsulin ResistanceAdipose Tissue, WhiteAdoptive TransferAnimalsBlood GlucoseCD8-Positive T-LymphocytesDiet, High-FatDisease Models, AnimalEnergy MetabolismLymphocyte ActivationMice, Inbred C57BLMice, KnockoutObesityPhenotypeSpleenBlood GlucoseMARCH1 protein, mouseUbiquitin-Protein LigasesMarch1memory CD8 T cellobesityT cell metabolism

Identifiers

PMID32973799
PMCPMC7461985
OpenAlexW3077123785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.