Evidence map›Paper›PMID 32973779›Full record

ReviewFrontiers in immunology2020

The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.

Sana O Alturki, Sawsan O Alturki, Jennifer Connors, Gina Cusimano, Michele A Kutzler, Abdullah M Izmirly, Elias K Haddad

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
1.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 79 citations in OpenAlex.

  1. Trial
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  4. Trial
  5. Antibody-dependent enhancement of coronaviruses.International journal of biological sciences · 2025
    Review
  6. Article
  7. Article
  8. Changing trends in Covid-19 publication in India by bibliometrics analysis.Journal of family medicine and primary care · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Immunogenicity of theVaccines · 2022
    Article
  16. Article
  17. Review
  18. The virological impacts of SARS-CoV-2 D614G mutation.Journal of molecular cell biology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sana O AlturkiDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Sawsan O AlturkiDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Jennifer ConnorsDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Gina CusimanoDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Michele A KutzlerDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Abdullah M IzmirlyDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Elias K HaddadDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Drexel University · USKing Abdulaziz University · SA

Funding

Investigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination. U19AI128910 · NIAID · DREXEL UNIVERSITY · PI HADDAD, ELIAS K · 2017 to 2021
$7.0M
A multi-tiered approach to develop validated assays to predict efficacy of a tetravalent live attenuated Dengue Virus vaccine in Phase II and Phase III clinical trialsR01AI125202 · NIAID · EMORY UNIVERSITY · PI SEKALY, RAFICK PIERRE · 2016 to 2020
$5.3M
NIAID NIH HHS R01 AI125202NIAID NIH HHS U19 AI128910
6 · The paper itself

Abstract

Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome infecting animals and humans. Coronaviruses have been described more than 70 years ago and contain many species. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are lethal species caused by human coronaviruses (HCoVs). Currently, a novel strain of HCoVs, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19). SARS-CoV-2 was first identified in December 2019 in Wuhan, the capital city of the Hubei province of China, and has since spread worldwide causing an outbreak in more than 200 countries. The SARS-CoV-2 outbreak was declared a pandemic on March 11th, 2020 and a public health emergency of international concern (PHEIC) in late January 2020 by the World Health Organization (WHO). SARS-CoV-2 infects the respiratory tract causing flu-like symptoms and, in some, may cause severe illness like pneumonia and multi-organ failure leading to death. Today, Covid-19 cases almost reaching 9 million, with more than 450 thousand deaths. There is an urgent demand for developing a vaccine since no effective therapies or vaccines have been approved to this day to prevent or minimize the spread of the infection. In this review, we summarized the furthest vaccines in the clinical pipeline.

Indexed as

Angiotensin-Converting Enzyme 2AnimalsAntibodies, NeutralizingAntibodies, ViralAntibody-Dependent EnhancementBetacoronavirusClinical Trials as TopicCoronavirus InfectionsCOVID-19COVID-19 VaccinesDrug EvaluationHumansPandemicsPeptidyl-Dipeptidase APneumonia, ViralSARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesPeptidyl-Dipeptidase ASpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Vaccinesantibody dependent enhancement (ADE)clinical trialcoronavirus disease 2019 (Covid-19)pandemicreceptor binding domain (RBD)Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)spike (S) protein

Identifiers

PMID32973779
PMCPMC7466534
OpenAlexW3051261383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.