Evidence map›Paper›PMID 32973739›Full record

ReviewFrontiers in immunology2020

The NLRP3 Inflammasome and Its Role in T1DM.

Xiaoxiao Sun, Haipeng Pang, Jiaqi Li, Shuoming Luo, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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  13. The role of regulated necrosis in diabetes and its complications.Journal of molecular medicine (Berlin, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoxiao SunDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Haipeng PangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jiaqi LiDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Shuoming LuoDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Gan HuangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Xia LiDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhiguo XieDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.
Zhiguang ZhouDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The NLRP3 (nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome is a protein complex expressed in cells. It detects danger signals and induces the production of active caspase-1 and the maturation and release of IL (interleukin)-33, IL-18, IL-1β and other cytokines. T1DM (type 1 diabetes mellitus) is defined as a chronic autoimmune disorder characterized by the autoreactive T cell-mediated elimination of insulin-positive pancreatic beta-cells. Although the exact underlying mechanisms are obscure, researchers have proposed that both environmental and genetic factors are involved in the pathogenesis of T1DM. Furthermore, immune responses, including innate and adaptive immunity, play an important role in this process. Recently, the NLRP3 inflammasome, a critical component of innate immunity, was reported to be associated with T1DM. Here, we review the assembly and function of the NLRP3 inflammasome. In addition, the activation and regulatory mechanisms that enhance or attenuate NLRP3 inflammasome activation are discussed. Finally, we focus on the relationship between the NLRP3 inflammasome and T1DM, as well as its potential value for clinical use.

Indexed as

Disease SusceptibilityAnimalsBiomarkersCytokinesDiabetes Mellitus, Type 1HumansInflammasomesLysosomesMitochondriaNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesSignal TransductionStructure-Activity RelationshipBiomarkersCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen Speciesautoimmune disorderIL-1βinnate immunityNLRP3 inflammasomeT1DM

Identifiers

PMID32973739
PMCPMC7481449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.