ReviewFrontiers in endocrinology2020
Hormonal Contraception and Bone Health in Adolescents.
Review in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Effects ofNutrients · 2026Trial
- Adolescent Endometriosis: From Clinical Management to an Early Recognition and Prevention-Oriented Paradigm-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Impact of estroprogestin therapies on bone health from adolescence to postmenopause.Journal of endocrinological investigation · 2026Review
- A Thematic Narrative Review of Osteoarthritis Risk Factors Across the Female Life Course.International journal of molecular sciences · 2026Review
- Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review.World journal of clinical pediatrics · 2026Review
- The Use of Combined Oral Contraceptives for ˃6 Months Is Not Associated with Body Fat or Bone Density, Regardless of Dietary Differences-A Pilot Study.Medicina (Kaunas, Lithuania) · 2026Article
- Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective.Frontiers in nutrition · 2026Article
- Medication-Related Impacts on Pediatric Bone Health.Journal of the Pediatric Orthopaedic Society of North America · 2025Review
- A predictive model for low bone mass in pediatric and adolescent patients with transfusion-dependent beta-thalassemia.Translational pediatrics · 2025Article
- Oral contraceptive use increases bone density and reduces the risk of osteoporosis.European journal of epidemiology · 2025Article
- Association between dietary choline intake and bone mineral density in adolescents: a NHANES-based study.BMC pediatrics · 2025Article
- Changes in Periprosthetic Bone Mineral Density Following Arthroplasty: An In-Depth Review and Current Perspectives.Current osteoporosis reports · 2025Review
- Review
- Bone Health for Gynaecologists.Medicina (Kaunas, Lithuania) · 2025Review
- Association Between Parity and Bone Mineral Density in the National Health and Nutrition Examination Survey.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- CORR Insights®: No Association Between Growth Hormone Therapy and Upper Extremity Physeal Tension Injuries: A Matched Case-control Study.Clinical orthopaedics and related research · 2025Article
- Influence of menstrual cycle and oral contraception on taxonomic composition and gas production in the gut microbiome.Journal of medical microbiology · 2025Article
- Basketball's Improvement in Bone Mineral Density Compared to Other Sports or Free Exercise Practice in Children and Adolescents: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Hormonal Contraception and Bone Metabolism: Emerging Evidence from a Systematic Review and Meta-Analysis of Studies on Post-Pubertal and Reproductive-Age Women.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Metformin in gynecological disorders: pathogenic insights and therapeutic implications.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormonal contraception is prescribed commonly to adolescents for myriad indications from pregnancy prevention to treatment for acne, hirsutism or dysmenorrhea. Although use of these hormones generally has no effect or benefits bone health in mature premenopausal women, the same may not be true for adolescents. The teen years are a critical period for acquiring peak bone strength. Sex hormones, growth hormone, and insulin-like growth factors (IGFs) interact to modulate the changes in bone size, geometry, mineral content, and microarchitecture that determine skeletal strength. Combined oral contraceptives (COCs) and intramuscular depo medroxyprogesterone (DMPA) can compromise the expected gains in adolescence by altering estrogen and IGF concentrations. Use of these medications has been associated with slower accrual of bone mineral density (BMD) and increased fracture risk in some studies. Far less is known about the skeletal effects of the newer long acting reversible contraceptives (LARCs). This review takes a critical look at the gaps in current knowledge of the skeletal effects of COCs, DMPA, and LARCs and underscores the need for additional research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.