Evidence map›Paper›PMID 32973590›Full record

ArticleFrontiers in psychiatry2020

COVID-19 Neurological Manifestations and Underlying Mechanisms: A Scoping Review.

Angela Wenting, Angélique Gruters, Yindee van Os, Sonja Verstraeten, Susanne Valentijn, Rudolf Ponds, Marjolein de Vugt

Open access · goldAbstract readScoping Review
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. COVID-19: a multi-organ perspective.Frontiers in cellular and infection microbiology · 2024
    Review
  5. Article
  6. Review
  7. Is a high chest CT severity score a risk factor for an increased incidence of long-term neuroimaging findings after COVID-19?Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  8. Review
  9. Article
  10. Observational
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cognitive impairment in a patient with COVID-19 on hemodialysis: Too dangerous to neglect!Hemodialysis international. International Symposium on Home Hemodialysis · 2021
    Article
  19. Development of the Adult Pandemic Attitude Scale (A-PAS).International journal of environmental research and public health · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Angela WentingDepartment of Medical Psychology, Catharina Hospital, Eindhoven, Netherlands.
Angélique GrutersDepartment of Medical Psychology, Catharina Hospital, Eindhoven, Netherlands.
Yindee van OsDepartment of Medical Psychology, Elkerliek Hospital, Helmond, Netherlands.
Sonja VerstraetenDepartment of Medical Psychology, Máxima Medical Center, Veldhoven, Netherlands.
Susanne ValentijnDepartment of Medical Psychology, Catharina Hospital, Eindhoven, Netherlands.
Rudolf PondsDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands.
Marjolein de VugtDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, Netherlands.
Radboud University Nijmegen · NLMaastricht University · NLCatharina Ziekenhuis · NLElkerliek Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the Corona Virus Disease 2019 (COVID-19) pandemic, the primary problem is respiratory-related, but there also is increasing evidence of central nervous system (CNS) involvement. This study aims to summarize the literature on neurological manifestations of COVID-19, underlying mechanisms of CNS involvement and cognitive consequences.

methodsA scoping review was conducted with multiple searches in PubMed, PsycInfo, and CINAHL databases. Full text articles in English were included if they involved humans with COVID-19. The search was updated twice, the latest on 19 May 2020.

resultsAfter screening 266 records and cross referencing, 85 articles were included. The articles were case studies, opinion papers, letters to editors, and a few observational studies. No articles were found regarding cognitive consequences in COVID-19 patients. All reported on neurological manifestations and/or underlying mechanisms of CNS involvement in COVID-19.

conclusionNeurological manifestations of COVID-19 vary from mild (e.g. loss of taste and smell, dizziness, headache) to severe (e.g. ischemic stroke, encephalitis). Underlying pathways are suggested to be both indirect (as a result of thrombotic complication, inflammatory consequences, hypoxia, blood pressure dysregulation), and direct (neurotropic properties of the virus). Since most articles were opinion papers and no studies have been conducted on cognitive consequences, further research is warranted.

Indexed as

cognitiveCorona Virus Disease 2019neurologicalneurotropicscoping review

Identifiers

PMID32973590
PMCPMC7472775
OpenAlexW3081464706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.