Evidence map›Paper›PMID 32973579›Full record

SynthesisFrontiers in psychiatry2020

Posttraumatic Stress Disorder and Nonadherence to Treatment in People Living With HIV: A Systematic Review and Meta-analysis.

Jianhua Hou, Jiangning Fu, Siyan Meng, Taiyi Jiang, Caiping Guo, Hao Wu, Bin Su, Tong Zhang

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianhua HouCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Jiangning FuInstitute of Psychology, Chinese Academy of Sciences, Beijing, China.
Siyan MengSchool of Public Health, Yale University, New Haven, CT, United States.
Taiyi JiangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Caiping GuoCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Hao WuCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Bin SuCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Tong ZhangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosttraumatic stress disorder (PTSD) is a commonly reported and serious complication among people living with HIV (PLWH). PTSD may significantly increase unintentional non-adherence to antiretroviral therapy. In this systematic review and meta-analysis, we aimed to pool the observational studies exploring the association between PTSD and medication adherence among PLWH.

methodsComprehensive searches were conducted in PubMed/Medline, Web of Science, PsycINFO, Google Scholar, and ProQuest to identify relevant articles and dissertations. A random effects meta-analysis with inverse variance weighting was used to summarize the odds ratio (OR) across studies. Meta-regression and subgroup analyses were also carried out to assess the moderation effects for potential factors.

resultsBy synthesizing 12 studies comprising 2489 participants, the pooled odd ratio of non-adherence to antiretroviral therapy was 1.19 (95% confidential interval (CI), 1.03-1.37,

conclusionsThis meta-analysis supports that PTSD is related to adherence in PLWH. The hypothesized mechanisms (avoidant behavior and cognitive impairment) underlying this association need further investigation. Overall, this study highlights that clinicians should thoughtfully integrate timely mental health intervention into routine care.

Indexed as

antiretroviral therapy adherencemeta-analysispeople living with HIVposttraumatic stress disordersystematic review

Identifiers

PMID32973579
PMCPMC7466667

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.