Evidence map›Paper›PMID 32973487›Full record

ArticleFrontiers in aging neuroscience2020

Antenatal Hypoxia Accelerates the Onset of Alzheimer's Disease Pathology in 5xFAD Mouse Model.

Guofang Shen, Shirley Hu, Zhen Zhao, Lubo Zhang, Qingyi Ma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  6. Very Early-Life Risk Factors for Developing Dementia: Evidence From Full Population Registers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Guofang ShenDepartment of Basic Sciences, The Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Shirley HuDepartment of Basic Sciences, The Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Zhen ZhaoDepartment of Physiology and Neuroscience, Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Lubo ZhangDepartment of Basic Sciences, The Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Qingyi MaDepartment of Basic Sciences, The Lawrence D. Longo MD Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, United States.
Loma Linda University · USUniversity of Southern California · US

Funding

Pericyte-neuronal crosstalk in health and Alzheimer's DiseaseR01AG061288 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2023
$2.1M
The protective effects of c-type natriuretic peptide in the neonatal brainR01NS112404 · NINDS · LOMA LINDA UNIVERSITY · PI MA, QINGYI · 2019 to 2023
$1.7M
Genetic interaction of PICALM and APOE in Alzheimer's diseaseR03AG063287 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHAO, ZHEN · 2019 to 2020
$330k
NIA NIH HHS R01 AG061288NIA NIH HHS R03 AG063287NINDS NIH HHS R01 NS112404
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with cognitive impairment and later dementia among the elderly. Mounting evidence shows that adverse maternal environments during the fetal development increase the risk of diseases later in life including neurological disorders, and suggests an early origin in the development of AD-related dementia (ADRD)

Indexed as

5xFAD mouseAlzheimer’s diseaseantenatal hypoxiacognitive impairmentgliosissynapse loss

Identifiers

PMID32973487
PMCPMC7472639
OpenAlexW3080440805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.