ArticleScientific reports2020
Integrating metabolomics and targeted gene expression to uncover potential biomarkers of fungal/oomycetes-associated disease susceptibility in grapevine.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 52 citations in OpenAlex.
- Decoding Biothreats With FT-ICR-MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics.Journal of mass spectrometry : JMS · 2026Article
- Decoding grapevine elicitation responses through cell culture metabolomics.BMC plant biology · 2026Article
- Integrative Metabolomics and Machine Learning Approach to Uncover Scab Resistance Markers in Mature Pecan Trees.Journal of agricultural and food chemistry · 2026Article
- Genome-wide identification, characterization, and expression profile analysis of the caffeic acid O-methyltransferases gene family in sweet orange (Citrus sinensis L.) in response to Penicillium digitatum infection.BMC plant biology · 2026Article
- Latest Developments in Mass Spectrometry-Based Techniques for Metabolomics Analysis.Advances in experimental medicine and biology · 2026Review
- Priming grapevines with oregano essential oil vapour results in a metabolomic shift eliciting resistance against downy mildew.BMC plant biology · 2024Article
- Grapevine gray mold disease: infection, defense and management.Horticulture research · 2024Article
- Metabolite profiling of chickpea (Frontiers in plant science · 2024Article
- Applicability of metabolomics to improve sustainable grapevine production.Frontiers in molecular biosciences · 2024Review
- A Multimethodological Approach for the Chemical Characterization of Edible Insects: The Case Study ofFoods (Basel, Switzerland) · 2023Article
- Decoding Metabolic Reprogramming in Plants under Pathogen Attacks, a Comprehensive Review of Emerging Metabolomics Technologies to Maximize Their Applications.Metabolites · 2023Review
- Secondary and primary metabolites reveal putative resistance-associated biomarkers againstFrontiers in plant science · 2023Article
- Preliminary insights on the metabolomics ofFrontiers in molecular biosciences · 2023Article
- Cultivation ofFrontiers in plant science · 2023Article
- Mixtures of Macro and Micronutrients Control Grape Powdery Mildew and Alter Berry Metabolites.Plants (Basel, Switzerland) · 2022Article
- Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated toFrontiers in plant science · 2022Article
- Graph Properties of Mass-Difference Networks for Profiling and Discrimination in Untargeted Metabolomics.Frontiers in molecular biosciences · 2022Article
- Raman Spectroscopy Applications in Grapevine: Metabolic Analysis of Plants Infected by Two Different Viruses.Frontiers in plant science · 2022Article
- Leaf Polyphenolic Profile as a Determinant of Croatian Native Grapevine Varieties' Susceptibility toFrontiers in plant science · 2022Article
- Transcriptomic and metabolomic integration as a resource in grapevine to study fruit metabolite quality traits.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitis vinifera, one of the most cultivated fruit crops, is susceptible to several diseases particularly caused by fungus and oomycete pathogens. In contrast, other Vitis species (American, Asian) display different degrees of tolerance/resistance to these pathogens, being widely used in breeding programs to introgress resistance traits in elite V. vinifera cultivars. Secondary metabolites are important players in plant defence responses. Therefore, the characterization of the metabolic profiles associated with disease resistance and susceptibility traits in grapevine is a promising approach to identify trait-related biomarkers. In this work, the leaf metabolic composition of eleven Vitis genotypes was analysed using an untargeted metabolomics approach. A total of 190 putative metabolites were found to discriminate resistant/partial resistant from susceptible genotypes. The biological relevance of discriminative compounds was assessed by pathway analysis. Several compounds were selected as promising biomarkers and the expression of genes coding for enzymes associated with their metabolic pathways was analysed. Reference genes for these grapevine genotypes were established for normalisation of candidate gene expression. The leucoanthocyanidin reductase 2 gene (LAR2) presented a significant increase of expression in susceptible genotypes, in accordance with catechin accumulation in this analysis group. Up to our knowledge this is the first time that metabolic constitutive biomarkers are proposed, opening new insights into plant selection on breeding programs.
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