Evidence map›Paper›PMID 32973319›Full record

ArticleScientific reports2020

Thyroid redox imbalance in adult Wistar rats that were exposed to nicotine during breastfeeding.

Rosiane Aparecida Miranda, Egberto Gaspar de Moura, Patrícia Novaes Soares, Thamara Cherem Peixoto, Bruna Pereira Lopes, Cherley Borba Vieira de Andrade, Elaine de Oliveira, Alex C Manhães, Caroline Coelho de Faria, Rodrigo Soares Fortunato and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Rosiane Aparecida MirandaPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Egberto Gaspar de MouraPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Patrícia Novaes SoaresPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Thamara Cherem PeixotoPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Bruna Pereira LopesPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Cherley Borba Vieira de AndradeTranslational Endocrinology Laboratory, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Elaine de OliveiraPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil.
Alex C ManhãesLaboratory of Neurophysiology, Biology Institute, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
Caroline Coelho de FariaLaboratory of Molecular Radiobiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rodrigo Soares FortunatoLaboratory of Molecular Radiobiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Patricia Cristina LisboaPhysiological Sciences Department, Laboratory of Endocrine Physiology, Biology Institute, Rio de Janeiro State University, Avenida 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil. pclisboa@uerj.br.
Universidade do Estado do Rio de Janeiro · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal nicotine exposure causes several consequences in offspring phenotype, such as obesity and thyroid dysfunctions. Nicotine exposure can increase oxidative stress levels, which could lead to thyroid dysfunction. However, the mechanism by which nicotine exposure during breastfeeding leads to thyroid gland dysfunction remains elusive. We aimed to investigate the long-term effects of maternal nicotine exposure on redox homeostasis in thyroid gland, besides other essential steps for thyroid hormone synthesis in rats from both sexes. Lactating Wistar rats were implanted with osmotic minipumps releasing nicotine (NIC, 6 mg/kg/day) or saline (control) from postnatal day 2 to 16. Offspring were analyzed at 180-day-old. NIC males showed lower plasma TSH, T

Indexed as

Breast FeedingAnimalsAntioxidantsBiomarkersFemaleGene Expression RegulationMaleMaternal ExposureNicotineOxidation-ReductionOxidative StressRats, WistarSex CharacteristicsThyroid GlandAntioxidantsBiomarkersNicotine

Identifiers

PMID32973319
PMCPMC7519108
OpenAlexW3088590489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.