ArticleScientific reports2020
Modeling undernutrition with enteropathy in mice.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Intestinal epithelial TLR4 knock out induces sex-specific effects on gut barrier and microbiome in an activity-based anorexia model.Gut microbes · 2026Article
- Enteropathy produced in mice by intergenerational transmission of small intestinal microbiota from undernourished children.Nature microbiology · 2026Article
- Combined Effects of Protein/Fat Deficiency and Disuse on Skeletal Muscle Mass and Function in Mice.Geriatrics & gerontology international · 2026Article
- Article
- Maternal undernutrition exacerbates microbiota-driven growth stunting through pre- and postnatal effects.Cell reports · 2025Article
- Effects of intergenerational transmission of small intestinal bacteria cultured from stunted Bangladeshi children with enteropathy.bioRxiv : the preprint server for biology · 2025Article
- Food-specific IgG antibodies and body mass index: multivariate analysis of clinical correlations in underweight populations.Frontiers in immunology · 2025Article
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
- Undernutrition-induced stunting-like phenotype inNarra J · 2024Article
- ViCE: An automated and quantitative program to assess intestinal tissue morphology.Journal of pathology informatics · 2024Article
- Postnatal supplementation with alarmins S100a8/a9 ameliorates malnutrition-induced neonate enteropathy in mice.Nature communications · 2024Article
- Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions.Cell reports · 2024Article
- Protection from environmental enteric dysfunction and growth improvement in malnourished newborns by amplification of secretory IgA.Cell reports. Medicine · 2024Article
- Paracellular permeability and tight junction regulation in gut health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.iScience · 2023Article
- Stunting as a Risk Factor of Soil-Transmitted Helminthiasis in Children: A Literature Review.Interdisciplinary perspectives on infectious diseases · 2022Review
- Validation of a Feed Protocol in a Mouse Model That Mimics Marasmic Malnutrition.Frontiers in veterinary science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Undernutrition is a global health issue leading to 1 out 5 all deaths in children under 5 years. Undernutrition is often associated with environmental enteric dysfunction (EED), a syndrome associated with increased intestinal permeability and gut inflammation. We aimed to develop a novel murine model of undernutrition with these EED features. Post-weaning mice were fed with low-protein diet (LP) alone or combined with a gastrointestinal insult trigger (indomethacin or liposaccharides). Growth, intestinal permeability and inflammation were assessed. LP diet induced stunting and wasting in post-weaning mice but did not impact gut barrier. We therefore combined LP diet with a single administration of indomethacin or liposaccharides (LPS). Indomethacin increased fecal calprotectin production while LPS did not. To amplify indomethacin effects, we investigated its repeated administration in addition to LP diet and mice exhibited stunting and wasting with intestinal hyperpermeability and gut inflammation. The combination of 3-weeks LP diet with repeated oral indomethacin administration induced wasting, stunting and gut barrier dysfunction as observed in undernourished children with EED. As noninvasive methods for investigating gut function in undernourished children are scarce, the present pre-clinical model provides an affordable tool to attempt to elucidate pathophysiological processes involved in EED and to identify novel therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.