Evidence map›Paper›PMID 32973233›Full record

ArticleScientific reports2020

MicroRNA molecules as predictive biomarkers of adaptive responses to strength training and physical inactivity in haemodialysis patients.

Ivana Spakova, Aurel Zelko, Miroslava Rabajdova, Peter Kolarcik, Jaroslav Rosenberger, Martina Zavacka, Maria Marekova, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ivana Spakova *Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Aurel Zelko *Department of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia. aurel.zelko@upjs.sk.
Miroslava Rabajdova *Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Peter KolarcikDepartment of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Jaroslav RosenbergerDepartment of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Martina ZavackaClinic of Vascular Surgery, East Slovak Institute of Cardiovascular Diseases, Kosice, 040 11, Slovakia.
Maria MarekovaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Andrea Madarasova Geckova *Department of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Jitse P van Dijk *Department of Health Psychology and Research Methodology, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, 040 11, Slovakia.
Sijmen A Reijneveld *Department of Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The miRNA-206 and miRNA-23a play an important role in muscle tissue hypertrophy, regeneration and atrophy. Both of these miRNAs have been highlighted as promising adaptation predictors; however, the available evidence on associations is inconclusive. Therefore, our aim was to assess the expression levels of these two miRNAs as predictors of change in muscle function during strength training and physical inactivity among dialysed patients. For this purpose, 46 haemodialysis patients were monitored for 12-weeks of either intradialytic strength training (EXG, n = 20) or physical inactivity during dialysis (CON, n = 26). In both groups of patients, we assessed the baseline expression levels of miRNA-23a and miRNA-206 and the isometric force generated during hip flexion (HF) contraction before and after the 12-week period. Among the EXG group, the expression of miRNA-206 predicted the change in HF (R

Indexed as

Physical Conditioning, AnimalResistance TrainingSedentary BehaviorAdaptation, PhysiologicalAgedBiomarkersCase-Control StudiesFemaleHumansMaleMicroRNAsMiddle AgedMuscle, SkeletalRenal DialysisBiomarkersMicroRNAs

Identifiers

PMID32973233
PMCPMC7519115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.