Evidence map›Paper›PMID 32973194›Full record

ArticleScientific reports2020

The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling.

Gilson Gonçalves Dos Santos, Juan Miguel Jimenéz-Andrade, Sarah A Woller, Enriqueta Muñoz-Islas, Martha Beatriz Ramírez-Rosas, Nobuko Ohashi, Glaucilene Ferreira Catroli, Yuya Fujita, Tony L Yaksh, Maripat Corr

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Research progress on rheumatoid arthritis-associated depression.Frontiers in behavioral neuroscience · 2022
    Review
  7. Review
  8. The gut-joint axis in rheumatoid arthritis.Nature reviews. Rheumatology · 2021
    Review
  9. Altered sensory innervation and pain hypersensitivity in a model of young painful arthritic joints: short- and long-term effects.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gilson Gonçalves Dos SantosDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Juan Miguel Jimenéz-AndradeUnidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.
Sarah A WollerDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Enriqueta Muñoz-IslasUnidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.
Martha Beatriz Ramírez-RosasUnidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.
Nobuko OhashiDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Glaucilene Ferreira CatroliDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Yuya FujitaDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, 9500 Gilman Dr. MC 0656, La Jolla, CA, 92093-0656, USA.
Tony L YakshDepartment of Anesthesiology, University of California, San Diego, La Jolla, CA, USA.
Maripat CorrDivision of Rheumatology, Allergy and Immunology, University of California, San Diego, 9500 Gilman Dr. MC 0656, La Jolla, CA, 92093-0656, USA. mpcorr@ucsd.edu.
University of California, San Diego · USAutonomous University of Tamaulipas · MXNational Institute of Neurological Disorders and Stroke · US

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
AIBP and regulation of neuropathic painR01NS102432 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILLER, YURY, YAKSH, TONY L. · 2017 to 2021
$3.0M
Sex, Stress and Immunity in the Acute to Chronic Pain TransitionR01NS099338 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YAKSH, TONY L. · 2017 to 2021
$1.8M
NIAMS NIH HHS T32 AR064194NINDS NIH HHS R01 NS099338NINDS NIH HHS R01 NS102432
6 · The paper itself

Abstract

The adult K/BxN transgenic mouse develops spontaneous autoimmune arthritis with joint remodeling and profound bone loss. We report that both males and females display a severe sustained tactile allodynia which is reduced by gabapentin but not the potent cyclooxygenase inhibitor ketorolac. In dorsal horn, males and females show increased GFAP

Indexed as

AnalgesicsAnimalsArthritis, ExperimentalFemaleGabapentinGanglia, SpinalHyperalgesiaKnee JointMaleMiceMice, TransgenicNerve TissueNeuralgiaNociceptive PainPhenotypeAnalgesicsGabapentin

Identifiers

PMID32973194
PMCPMC7515905
OpenAlexW3088498982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.