ArticleMolecular psychiatry2021
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Substance use and spine density: a systematic review and meta-analysis of preclinical studies.Molecular psychiatry · 2024Pooled it
- Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder.Frontiers in psychiatry · 2023Pooled it
- Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial.Molecular psychiatry · 2023Trial
- Psilocybin's effect on human brain synaptic plasticity.Translational psychiatry · 2026Article
- Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Molecular psychiatry · 2026Article
- Assessment of noninvasive quantification of [European journal of nuclear medicine and molecular imaging · 2026Article
- Distinguishing task-evoked dynamic brain networks from intrinsic activity with tensor component analysis.Brain imaging and behavior · 2026Article
- Synaptic Density in Multiple Sclerosis: An In Vivo Study Using [Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning.EJNMMI physics · 2025Article
- The potential of non-psychedelic 5-HT2A agents in the treatment of substance use disorders: a narrative review of the clinical literature.Expert opinion on pharmacotherapy · 2025Review
- Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [EJNMMI research · 2024Article
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [European journal of nuclear medicine and molecular imaging · 2024Article
- First-in-Human Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Follow-Up of a Sample of Patients with Substance Use Disorder After Completing a Rehabilitation Program in a Continuous Care Unit in Eastern Province of Saudi Arabia, from 2012 to 2022: A Retrospective Study.Neuropsychiatric disease and treatment · 2024Article
- Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.Dialogues in clinical neuroscience · 2023Review
- First-in-Human PET Imaging of [Molecular imaging · 2023Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the effects of cannabis use on the brain is important. Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural changes in the hippocampus both pre- and post-synaptically. Whether similar alterations exist in human cannabis users, has not yet been demonstrated in vivo. Positron emission tomography (PET) and [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.