Evidence map›Paper›PMID 32973149›Full record

ArticleNature communications2020

Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients.

Brendan A Daisley, Ryan M Chanyi, Kamilah Abdur-Rashid, Kait F Al, Shaeley Gibbons, John A Chmiel, Hannah Wilcox, Gregor Reid, Amanda Anderson, Malcolm Dewar and 3 more

Erratum issued 2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05790356 narecruitingnot on this mapstarted 2023, after this paper: background citation

Fecal Microbial Transplantation for Rheumatoid Arthritis Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2023 to 2026Enrolled30ConditionsArthritis, Arthritis, Rheumatoid, Fecal Microbiota TransplantationArmsFecal Microbial transplant, Placebo capsules
NCT05802121 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

The Role of Akkermansia Muciniphilia in Combating the Metabolic Effects of Androgen Deprivation Therapy in Men With Metastatic Prostate Cancer

TypeinterventionalSponsorWestern UniversityRan2025 to 2027Enrolled30ConditionsProstate Cancer, Metabolic Syndrome, Obesity, Cardiovascular MorbidityArmsApple Cider Vinegar
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 128 citations in OpenAlex.

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  12. The Role of Akkermansia muciniphila in Disease Regulation.Probiotics and antimicrobial proteins · 2025
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Brendan A DaisleyDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0001-5999-5792
Ryan M ChanyiDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0002-0189-0303
Kamilah Abdur-RashidDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.
Kait F AlDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0002-5905-6581
Shaeley GibbonsDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.
John A ChmielDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0001-6324-2777
Hannah WilcoxDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.
Gregor ReidDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0001-9658-5696
Amanda AndersonDepartment of Surgery, Division of Urology, Schulich School of Medicine, London, ON, N6A 5C1, Canada.
Malcolm DewarDepartment of Surgery, Division of Urology, Schulich School of Medicine, London, ON, N6A 5C1, Canada.
Shiva M NairDepartment of Surgery, Division of Urology, Schulich School of Medicine, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0002-1075-3730
Joseph ChinDepartment of Surgery, Division of Urology, Schulich School of Medicine, London, ON, N6A 5C1, Canada.
Jeremy P BurtonDepartment of Microbiology and Immunology, The University of Western Ontario, London, ON, N6A 5C1, Canada. jeremy.burton@lawsonresearch.com.ORCID http://orcid.org/0000-0002-3591-6436
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abiraterone acetate (AA) is an inhibitor of androgen biosynthesis, though this cannot fully explain its efficacy against androgen-independent prostate cancer. Here, we demonstrate that androgen deprivation therapy depletes androgen-utilizing Corynebacterium spp. in prostate cancer patients and that oral AA further enriches for the health-associated commensal, Akkermansia muciniphila. Functional inferencing elucidates a coinciding increase in bacterial biosynthesis of vitamin K2 (an inhibitor of androgen dependent and independent tumor growth). These results are highly reproducible in a host-free gut model, excluding the possibility of immune involvement. Further investigation reveals that AA is metabolized by bacteria in vitro and that breakdown components selectively impact growth. We conclude that A. muciniphila is a key regulator of AA-mediated restructuring of microbial communities, and that this species may affect treatment response in castrate-resistant cohorts. Ongoing initiatives aimed at modulating the colonic microbiota of cancer patients may consider targeted delivery of poorly absorbed selective bacterial growth agents.

Indexed as

Abiraterone AcetateAkkermansiaAndrogen AntagonistsAndrogensBacteriaFecesGastrointestinal MicrobiomeHumansMaleProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantRNA, Ribosomal, 16SVerrucomicrobiaVitamin K 2Abiraterone AcetateAndrogen AntagonistsAndrogensRNA, Ribosomal, 16SVitamin K 2

Identifiers

PMID32973149
PMCPMC7515896
OpenAlexW3088710714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.