Evidence map›Paper›PMID 32973073›Full record

ArticleBMJ open diabetes research & care2020

Decreased miR-150 in obesity-associated type 2 diabetic mice increases intraocular inflammation and exacerbates retinal dysfunction.

Fei Yu, Samantha Chapman, Dylan Luc Pham, Michael Lee Ko, Beiyan Zhou, Gladys Y-P Ko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  12. The Related Metabolic Diseases and Treatments of Obesity.Healthcare (Basel, Switzerland) · 2022
    Review
  13. Microvascular Inflammation and Cardiovascular Prevention: The Role of Microcirculation as Earlier Determinant of Cardiovascular Risk.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fei YuVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Samantha ChapmanVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Dylan Luc PhamVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Michael Lee KoVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA.
Beiyan ZhouImmunology, UConn Health, Farmington, Connecticut, USA.
Gladys Y-P KoVeterinary Integrative Biosciences, Texas A&M University, College Station, Texas, USA gko@cvm.tamu.edu.ORCID 0000-0002-6854-777X
Texas A&M University · USBlinn College · USUConn Health · US

Funding

MiR-150 regulated adiose tissue B cells in obesityR01DK121805 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T, ZHOU, BEIYAN · 2020 to 2024
$2.0M
NIDDK NIH HHS R01 DK121805
6 · The paper itself

Abstract

introductionDiabetic retinopathy (DR) is the leading cause of blindness among the working population in the USA. Current therapies, including anti-vascular endothelial growth factor treatments, cannot completely reverse the visual defects induced by DR. MicroRNA-150 (miR-150) is a regulator that suppresses inflammation and pathological angiogenesis. In patients with diabetes, miR-150 is downregulated. As chronic inflammation is a major contributor to the pathogenesis of DR, whether diabetes-associated decrease of miR-150 is merely associated with the disease progression or decreased miR-150 causes retinal inflammation and pathological angiogenesis is still unknown. RESEARCH DESIGN AND

methodsWe used high-fat diet (HFD)-induced type 2 diabetes (T2D) in wild type (WT) and miR-150 knockout (miR-150

resultsWe found that WT mice fed with an HFD for only 1 month had a significant decrease of miR-150 in the blood and retina, and retinal light sensitivity also decreased. The miR-150

conclusionThese data suggest that decreased miR-150 caused by obesity or diabetic insults is not merely correlated to the disease progression, but it contributes to the retinal dysfunction and inflammation, as well as the development of DR.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2MicroRNAsAnimalsInflammationMiceMice, ObeseObesityMicroRNAsMirn150 microRNA, mouseblindnessdiabetes mellitusdiabetic retinopathyobesityType 2

Identifiers

PMID32973073
PMCPMC7517560
OpenAlexW3088816009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.