ArticleBMJ open diabetes research & care2020
Diabetes mellitus is associated with a higher risk for major depressive disorder in women than in men.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 83 citations in OpenAlex.
- Mental Health Among Adults with Diabetes in Spain: A Population-Based Matched Study of Emotional Well-Being, Depressive Symptoms, and Psychiatric Medication Use.Healthcare (Basel, Switzerland) · 2026Article
- Sex-Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu-erh Tea.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Co-Expressed MicroRNAs Identify Potential Mechanisms Underlying Risk for Multimorbid Depression and Type 2 Diabetes in Midlife Women.bioRxiv : the preprint server for biology · 2026Article
- Association between mental disorder and hospitalization outcomes in neurogenic bladder: a retrospective nationwide inpatient sample database study.International urology and nephrology · 2026Article
- Sex Disparity in Suicide Mortality among Patients with Type 2 Diabetes: A Nationwide Population-Based Cohort Study.Endocrinology and metabolism (Seoul, Korea) · 2026Article
- Association between type 2 diabetes mellitus and psychosocial burdens in older adults in Germany: findings from the longitudinal Gesundheit 65+ study.BMJ open diabetes research & care · 2026Article
- [Mental and neurocognitive diseases and diabetes mellitus (Update 2026)].Wiener klinische Wochenschrift · 2026Review
- Co-expressed MicroRNAs Associated with An Elevated Psychometabolic Risk Phenotype in Women during Midlife.medRxiv : the preprint server for health sciences · 2026Article
- Systematic review and meta-analysis on depression burden among Type 2 diabetes patients in India.Diabetology & metabolic syndrome · 2026Review
- Co-expressed microRNAs associated with elevated psychometabolic risk phenotype in women during midlife.Frontiers in endocrinology · 2026Article
- Temporal and geographic trends in mortality involving co-occurring depression and diabetes mellitus in U. S., 1999-2023.Frontiers in medicine · 2026Article
- Effects of Continuous Glucose Monitoring on Glycemic Control, Mental Health and Self-Management in Adults with Type 1 Diabetes: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- The Beck Depression Inventory-II scores of adults with type 1 diabetes in Japan: Analysis using the Juntendo-Aso Type 1 Diabetes (JAT-1) Cohort.Journal of diabetes investigation · 2025Article
- Article
- The relationship between depressive symptoms and glycemic control is stronger in women with type 2 diabetes in South Asians: Results from a cross-sectional multicenter study.Journal of diabetes investigation · 2025Article
- Depressive symptoms and associated factors among patients with diabetes in public primary healthcare facilities in Kuwait city, 2024.Scientific reports · 2025Article
- Trends in Depression Among Hospitalized Patients with Type 2 Diabetes in Spain (2017-2023): A Population-Based Analysis with a Focus on Sex Differences and In-Hospital Outcomes.Journal of clinical medicine · 2025Article
- Comorbidity Networks From Population-Wide Health Data: Aggregated Data of 8.9M Hospital Patients (1997-2014).Scientific data · 2025Article
- Prospective longitudinal study of dynamic depressive symptom trajectories and diabetes onset risk in older adults: a 10-year follow-up of the HRS and ELSA cohorts.Frontiers in public health · 2025Article
- Gender differences in the relationship between depressive symptoms and diabetes associated with cognitive-affective symptoms.BJPsych open · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBoth diabetes mellitus and being female significantly increase the risk of being diagnosed with major depressive disorder (MDD). The diagnosis of MDD, combined with diabetes mellitus, can be detrimental in terms of mortality and morbidity. We aimed at investigating the impact of diabetes mellitus on the gender gap in MDD over the course of a human lifetime. RESEARCH DESIGN AND
methodsIn a cross-sectional study over the course of 17 years, medical claims data of the general Austrian population (n=8 996 916) between 1997 and 2014 was analyzed. Of these, 123 232 patients with diabetes mellitus were extracted and compared with non-diabetic controls.
resultsIn a cohort of 123 232 patients with diabetes mellitus and 1 933 218 controls (52% females, 48% males), women with diabetes had 2.55 times increased ORs to be diagnosed with MDD compared with women without diabetes (95% CI 2.48 to 2.62, p<0.001) between the age of 30 and 69 years. The effect of diabetes mellitus on the prevalence of MDD was significantly smaller in men (OR=1.85, 95% CI 1.80 to 1.91, p<0.001). Between 0 and 30 years and after age 70 years, the gender gap of MDD was not different between patients with and without diabetes mellitus. The peak of the gender gap in MDD in patients with diabetes mellitus was around the age of 40-49 years. A sensitivity analysis identified overweight, obesity and alcohol dependence as the most potent influencing factors of the widening of the gender gap among patients with diabetes mellitus.
conclusionsDiabetes mellitus is a stronger risk factor for MDD in women than in men, with the greatest width of the gender gap between 40 and 49 years. High-risk patients for MDD, such as overweight female patients with diabetes, should be more carefully assessed and monitored.
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