ArticleScience (New York, N.Y.)2020
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
4 registry-linked trialsOpen access · hybridAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,777 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,777citing papers in PubMed, 4 pooled it
57.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Viral Excretion in Contact Subjects at High/Moderate Risk of Coronavirus 2019-nCoV Infection
Interest of Plasma Exchange in Patients With Anti-interferon Type 1 Autoantibodies With Severe COVID-19 -
Early Interferon-beta Treatment for West-Nile Virus Infection
Impaired Type I IFN Immunity Due to Autoantibodies or a Genetic Defect: a Prospective National Cohort
Who cites it
1,777 citing papers in PubMed, 4 syntheses or guidelines pooled it, 2,815 citations in OpenAlex.
- Systematic Review and Meta-analysis of Anti-interferon Auto-antibodies in Infectious Diseases.Journal of clinical immunology · 2026Pooled it
- The immunopathological spectrum of COVID-19: from cytokine storm to autoimmunity-a systematic review.Frontiers in medicine · 2026Pooled it
- Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- COVID-19 infection in children with blood cancer: A systematic review.Annals of hematology · 2025Pooled it
- Effect of inhaled interferon-β1a on SARS-CoV-2 diversity and evolution.Microbiology spectrum · 2026Trial
- Trial
- SARS-CoV-2-induced IgG repertoires shape T cell responses, microRNA regulation, and autoreactivity according to disease severity.Journal of translational autoimmunity · 2026Article
- High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C.Journal of human immunity · 2026Article
- Highly neutralizing anti-IFN-ω autoantibodies underlie severe pediatric adenovirus infection.Journal of human immunity · 2026Article
- Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.Journal of human immunity · 2026Article
- Prevalence of neutralizing autoantibodies against type I interferon in dengue patients.Journal of human immunity · 2026Article
- Autoantibodies neutralizing type I interferons in COVID-19 patients from southern Brazil.Journal of human immunity · 2026Article
- Approach to the patient with APS-1/APECED.The Journal of clinical endocrinology and metabolism · 2026Article
- Evidence for maternal autoantibodies in the pathogenesis of preterm birth.Nature immunology · 2026Article
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.American journal of human genetics · 2026Article
- High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons.The Journal of infectious diseases · 2026Article
- A knockout screening platform for interferon-stimulated genes in respiratory cells identifies LY6E as a dominant antiviral effector against coronaviruses.bioRxiv : the preprint server for biology · 2026Article
- Mostly getting along -Borrelia burgdorferi and its manipulation of the host immune system.ImmunoHorizons · 2026Review
- Mechanisms of antibody-dependent enhancement and its research progress in animal coronaviruses.Veterinary research · 2026Review
1,717 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
109 authors at 20 institutions in 12 countries.
Paul Bastard *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org.ORCID 0000-0002-5926-8437
Lindsey B Rosen *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-5894-3878
Qian Zhang *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9040-3289
Eleftherios Michailidis *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9907-4346
Hans-Heinrich Hoffmann *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-0554-0244
Yu Zhang *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Karim Dorgham *Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France.ORCID 0000-0001-9539-3203
Quentin Philippot *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Jérémie Rosain *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Vivien Béziat *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-4020-824X
Jérémy ManryLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-5998-2051
Elana ShawLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-9265-8026
Liis HaljasmägiInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0001-7162-9808
Pärt PetersonInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0001-6755-791X
Lazaro LorenzoLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-6648-8684
Lucy BizienLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-9163-9122
Sophie Trouillet-AssantHospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.ORCID 0000-0001-6439-4705
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-3432-3137
Adriana Almeida de JesusLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Alexandre BelotInternational Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.ORCID 0000-0003-4902-5332
Anne KallasteInternal Medicine Clinic, Tartu University Hospital, Tartu, Estonia.ORCID 0000-0002-7492-667X
Emilie CatherinotPneumology Department, Foch Hospital, Suresne, France.
Yacine Tandjaoui-LambiotteAvicenne Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Bobigny, INSERM U1272 Hypoxia and Lung, Bobigny, France.ORCID 0000-0003-1123-4788
Jeremie Le PenLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7025-9526
Gaspard KernerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-0146-9428
Benedetta BigioSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7291-5638
Yoann SeeleuthnerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Rui YangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-4427-2158
Alexandre BolzeHelix, San Mateo, CA, USA.ORCID 0000-0001-7399-2766
András N SpaanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-5981-7259
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Michael S AbersLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Alessandro AiutiIRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0002-5398-1717
Giorgio CasariIRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.
Vito LampasonaIRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0001-5162-8445
Lorenzo PiemontiIRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.ORCID 0000-0002-2172-2198
Fabio CiceriIRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy.
Kaya BilguvarDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7313-7652
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Marc VasseService de Biologie Clinique and UMR-S 1176, Hôpital Foch, Suresnes, France.
David M SmadjaINSERM UMR-S 1140, Biosurgical Research Laboratory (Carpentier Foundation), Paris University and European Georges Pompidou Hospital, Paris, France.
Mélanie MigaudLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-3062-1214
Jérome HadjadjLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.ORCID 0000-0002-2520-3272
Benjamin TerrierDepartment of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), University of Paris, Paris, France.ORCID 0000-0001-6612-7336
Darragh DuffyTranslational Immunology Laboratory, Institut Pasteur, Paris, France.ORCID 0000-0002-8875-2308
Lluis Quintana-MurciHuman Evolutionary Genetics Unit, Institut Pasteur, CNRS UMR 2000, 75015, Paris, France.ORCID 0000-0003-2429-6320
Diederik van de BeekAmsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands.ORCID 0000-0002-4571-044X
Lucie RousselDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.ORCID 0000-0001-5355-702X
Donald C VinhDepartment of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.ORCID 0000-0003-1347-7767
Stuart G TangyeGarvan Institute of Medical Research, Darlinghurst 2010, NSW, Sydney, Australia.ORCID 0000-0002-5360-5180
Filomeen HaerynckDepartment of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
David DalmauInfectious Diseases and HIV Service, Hospital Universitari Mutua Terrassa, Universitat de Barcelona, Fundació Docència i Recerca Mutua Terrassa, Terrassa, Barcelona, Catalonia, Spain.ORCID 0000-0003-1936-478X
Javier Martinez-PicadoIrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain.ORCID 0000-0002-4916-2129
Petter BrodinScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Karolinska, Sweden.ORCID 0000-0002-8103-0046
Michel C NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-0592-8564
Stéphanie Boisson-DupuisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-7115-116X
Carlos Rodríguez-GallegoDepartment of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.ORCID 0000-0002-4344-8644
Guillaume VogtNeglected Human Genetics Laboratory, INSERM, University of Paris, Paris, France.
Trine H MogensenDepartment of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark.ORCID 0000-0002-1853-9704
Andrew J OlerBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-6310-0434
Jingwen GuBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA.
Peter D BurbeloDivision of Intramural Research, National Institute of Dental Craniofacial Research (NIDCR), NIH, Bethesda, MD, USA.ORCID 0000-0003-1717-048X
Jeffrey I CohenLaboratory of Infectious Diseases, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-0238-7176
Andrea BiondiPediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
Laura Rachele BettiniPediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.ORCID 0000-0002-0280-1704
Mariella D'AngioPediatric Department and Centro Tettamanti-European Reference Network PaedCan, EuroBloodNet, MetabERN-University of Milano-Bicocca-Fondazione MBBM-Ospedale, San Gerardo, Monza, Italy.
Paolo BonfantiDepartment of Infectious Diseases, San Gerardo Hospital - University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-7289-8823
Patrick RossignolUniversity of Lorraine, Plurithematic Clinical Investigation Centre INSERM CIC-P 1433, INSERM U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
Julien MayauxIntensive Care Unit, Pitié-Salpétrière Hospital, Paris University, AP-HP, Paris, France.
Frédéric Rieux-LaucatLaboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, University of Paris, Imagine Institute, Paris, France.ORCID 0000-0001-7858-7866
Eystein S HusebyeDepartment of Clinical Science and K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway.ORCID 0000-0002-7886-2976
Francesca FuscoHuman Molecular Genetics Laboratory, Institute of Genetics and Biophysics, "A. Buzzati-Traverso" Consiglio Nazionale delle Ricerche, Naples, Italy.
Matilde Valeria UrsiniHuman Molecular Genetics Laboratory, Institute of Genetics and Biophysics, "A. Buzzati-Traverso" Consiglio Nazionale delle Ricerche, Naples, Italy.
Luisa ImbertiCentro di Ricerca Emato-oncologica AIL (CREA) Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Alessandra SottiniCentro di Ricerca Emato-oncologica AIL (CREA) Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Simone PagheraCentro di Ricerca Emato-oncologica AIL (CREA) Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Eugenia Quiros-RoldanDepartment of Infectious and Tropical Diseases, University of Brescia and ASST Spedali di Brescia, Brescia, Italy.
Camillo RossiDirezione Sanitaria, ASST Spedali Civili di Brescia, Brescia, Italy.
Riccardo CastagnoliDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.ORCID 0000-0003-0029-9383
Daniela MontagnaLaboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Amelia LicariDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.ORCID 0000-0002-1773-6482
Gian Luigi MarsegliaDepartment of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Xavier DuvalINSERM CIC 1425, Paris, France.
Jade GhosnInfection, Antimicrobials, Modelling, Evolution (IAME), INSERM, UMRS1137, University of Paris, Paris, France.
HGID Lab
NIAID-USUHS Immune Response to COVID Group
COVID Clinicians
COVID-STORM Clinicians
Imagine COVID Group
French COVID Cohort Study Group
Milieu Intérieur Consortium
CoV-Contact Cohort
Amsterdam UMC Covid-19 Biobank
COVID Human Genetic Effort
John S TsangCenter for Human Immunology, NIH, Bethesda, MD, USA.ORCID 0000-0003-3186-3047
Raphaela Goldbach-ManskyLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-7865-5769
Kai KisandInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5426-4648
Michail S LionakisLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-2603-0323
Shen-Ying ZhangLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Steven M Holland *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0003-3207-5464
Guy Gorochov *Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses, (CIMI-Paris), Paris, France.
Emmanuelle Jouanguy *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-7358-9157
Charles M Rice *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
Aurélie Cobat *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7209-6257
Luigi D Notarangelo *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8335-0262
Laurent Abel *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7016-6493
Helen C Su *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Jean-Laurent Casanova *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. jean-laurent.casanova@rockefeller.edu paul.bastard@institutimagine.org.ORCID 0000-0002-7782-4169
Inserm · FRNational Institutes of Health · USUniversité Claude Bernard Lyon 1 · FRVita-Salute San Raffaele University · ITHoward Hughes Medical Institute · USRockefeller University · USUniversidad Fernando Pessoa Canarias · ESInstitute of Genetics and Biophysics · ITUniversitat de Vic - Universitat Central de Catalunya · ESUniversity of Milano-Bicocca · ITUniversity of Pavia · ITUniversity of Tartu · EEAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITHelix (United States) · USAmsterdam Neuroscience · NLAssistance Publique – Hôpitaux de Paris · FRCentre National de la Recherche Scientifique · FRGarvan Institute of Medical Research · AUGhent University Hospital · BEHôpital Foch · FR
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MRegulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CASANOVA, JEAN-LAURENT · 2004 to 2021
$29.8MUnderstanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2014 to 2023
$26.0MYale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8MMonogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7MVirology CoreP01AI138938 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2018 to 2022
$8.4MType I interferon-stimulated genes and the antiviral immune responseR01AI091707 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2011 to 2020
$5.5MNHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9MObesity dysregulates immune and metabolic status in asthma and alters infection susceptibility.K08AI135091 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI HENRICKSON, SARAH E · 2019 to 2023
$935kHoward Hughes Medical InstituteMRF_ C0483NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR001866NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006504NIAID NIH HHS K08 AI135091NIAID NIH HHS P01 AI061093NIAID NIH HHS P01 AI138938NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI091707NIAID NIH HHS U19 AI111825
Abstract
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Indexed as
AdultAgedAged, 80 and overAntibodies, NeutralizingAsymptomatic InfectionsAutoantibodiesBetacoronavirusCase-Control StudiesCoronavirus InfectionsCOVID-19Critical IllnessFemaleHumansImmunoglobulin GInterferon alpha-2Interferon Type IAntibodies, NeutralizingAutoantibodiesImmunoglobulin GInterferon alpha-2interferon omega 1Interferon Type I
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