ReviewHeart, lung & circulation2020
COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System.
Review in Heart, lung & circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Retinal microvascular impairment in COVID-19 patients: A meta-analysis.Immunity, inflammation and disease · 2022Pooled it
- Pre-existing diabetic retinopathy as a prognostic factor for COVID-19 outcomes amongst people with diabetes: A systematic review.Diabetes research and clinical practice · 2022Pooled it
- Effect of COVID-19 on Retinal and Choroidal Microvasculature in the Pediatric Population: A Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- Renin and 1-year mortality in critically ill patients with ARDS: trajectories, discrimination, and survival analysis.Frontiers in medicine · 2026Article
- Cardiorenal outcomes after herpes zoster reactivation in COVID-19 survivors from a global TriNetX study.Scientific reports · 2025Article
- COVID-19's effects on microvascular structure in a healthy retina: an OCTA study.International journal of ophthalmology · 2025Article
- Perioperative cardiovascular risk and preventions of patients with post-COVID-19 condition.Heliyon · 2024Review
- Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review.Life (Basel, Switzerland) · 2024Review
- Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection.JCI insight · 2022Article
- Ocular sequelae in severe COVID-19 recovered patients of second wave.Indian journal of ophthalmology · 2022Observational
- Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19).Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- COVID-19 with Rapid Progression to Hypoxemia Likely due to Imbalance between Ventilation and Blood Flow: A Case Report.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2022Article
- COVID-19 in patients with cardiac disease: Impact and variables associated with mortality in a cardiology center in Brazil.American heart journal plus : cardiology research and practice · 2021Article
- Heart, Lung and Circulation in the COVID-19 Era: About COVID-19, Not Just About COVID-19.Heart, lung & circulation · 2021Article
- Coronary microvascular dysfunction pathophysiology in COVID-19.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Article
- A time-resolved proteomic and prognostic map of COVID-19.Cell systems · 2021Article
- Dysregulation of COVID-19 related gene expression in the COPD lung.Respiratory research · 2021Article
- Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography.Biomedicines · 2021Article
- Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia Assessed by Optical Coherence Tomography Angiography.Biomedicines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people, with thousands of fatalities. It has prompted global efforts in research, with focus on the pathophysiology of coronavirus disease-19 (COVID-19), and a rapid surge of publications. COVID-19 has been associated with a myriad of clinical manifestations, including the lungs, heart, kidneys, central nervous system, gastrointestinal system, skin, and blood coagulation abnormalities. The endothelium plays a key role in organ dysfunction associated with severe infection, and current data suggest that it is also involved in SARS-CoV-2-induced sepsis. This critical review aimed to address a possible unifying mechanism underlying the diverse complications of COVID-19: microvascular dysfunction, with emphasis on the renin-angiotensin system. In addition, research perspectives are suggested in order to expand understanding of the pathophysiology of the infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.