Evidence map›Paper›PMID 32972455›Full record

ArticleBreast cancer research : BCR2020

Outdoor air pollution and terminal duct lobular involution of the normal breast.

Nicole M Niehoff, Alexander P Keil, Rena R Jones, Shaoqi Fan, Gretchen L Gierach, Alexandra J White

Open access · goldAbstract read
In one paragraph

Article in Breast cancer research : BCR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA. nicole.niehoff@nih.gov.ORCID 0000-0002-5852-3010
Alexander P KeilEpidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA.
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Shaoqi FanIntegrative Tumor Biology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Gretchen L GierachIntegrative Tumor Biology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA.
National Cancer Institute · USNational Institute of Environmental Health Sciences · USUniversity of North Carolina at Chapel Hill · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005Intramural NIH HHS ZIA ES103332NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundExposure to certain outdoor air pollutants may be associated with a higher risk of breast cancer, though potential underlying mechanisms are poorly understood. We examined whether outdoor air pollution was associated with involution of terminal duct lobular units (TDLUs), the histologic site where most cancers arise and an intermediate marker of breast cancer risk.

methodsPathologist-enumerated TDLUs were assessed in H&E (hematoxylin and eosin)-stained breast tissue sections from 1904 US women ages 18-75 who donated to the Susan G. Komen Tissue Bank (2009-2012). The 2009 annual fine particulate matter < 2.5 μm in diameter (PM

resultsPM

conclusionsHigher PM

Indexed as

AdolescentAdultAgedAir PollutantsBreastBreast NeoplasmsCohort StudiesDisease SusceptibilityFemaleHumansMammary Glands, HumanMiddle AgedParticulate MatterPostmenopausePremenopauseRisk FactorsAir PollutantsParticulate MatterAir pollutionBreast cancerBreast involutionParticulate matterTerminal duct lobular units

Identifiers

PMID32972455
PMCPMC7513536
OpenAlexW3088194074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.