ReviewRespiratory research2020
Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19.
Review in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Performance of the Ventilatory Ratio to Predict Intubation in Patients With COVID-19 Acute Respiratory Distress Syndrome.Critical care explorations · 2026Article
- Article
- Happy Hypoxia With SARS-CoV-2 Pneumonitis: A Life-Threatening Case of a Medical Doctor.Cureus · 2025Article
- Acute Respiratory Failure From Early Pandemic COVID-19: Noninvasive Respiratory Support vs Mechanical Ventilation.CHEST critical care · 2024Article
- Evolution of the oxyhemoglobin dissociation curve in COVID-19 related ARDS patients.Frontiers in physiology · 2024Article
- Improved understanding of the respiratory drive pathophysiology could lead to earlier spontaneous breathing in severe acute respiratory distress syndrome.European journal of anaesthesiology and intensive care · 2023Article
- Kidney Injury in Critically Ill Patients with COVID-19 - From Pathophysiological Mechanisms to a Personalized Therapeutic Model.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Review
- Ratio of Oxygen Saturation to Inspired Oxygen, ROX Index, Modified ROX Index to Predict High Flow Cannula Success in COVID-19 Patients: Multicenter Validation Study.The western journal of emergency medicine · 2023Article
- High variability of COVID-19 case fatality rate in Germany.BMC public health · 2023Article
- Role of prognostic scores in predicting in-hospital mortality and failure of non-invasive ventilation in adults with COVID-19.Internal and emergency medicine · 2022Article
- Intubation Timing in COVID-19 Based on ROX Index and Association With Patient Outcomes.Respiratory care · 2022Article
- Correlation of the SpOMedicina intensiva · 2022Article
- Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection.Respiratory medicine · 2022Observational
- Article
- CT score in COVID-19-related pneumonia, the radiologist, and the internist. Trying to unmask who is "the good", who is "the bad" and who is "the ugly".Internal and emergency medicine · 2022Article
- Pulmonary surfactant and COVID-19: A new synthesis.QRB discovery · 2022Article
- Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units.Critical care (London, England) · 2021Observational
- The Natural History of a Patient With COVID-19 Pneumonia and Silent Hypoxemia.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021Article
- Conceptions of the pathophysiology of happy hypoxemia in COVID-19.Respiratory research · 2021Article
- Happy hypoxemia, or blunted ventilation?Respiratory research · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the article "The pathophysiology of 'happy' hypoxemia in COVID-19," Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patients with COVID-19 who exhibit severe hypoxemia. The authors review well-known mechanisms that contribute to development of hypoxemia in patients with pneumonia, but are less clear as to why patients should be free of respiratory discomfort despite arterial oxygen levels commonly regarded as life threatening. The authors propose a number of therapeutic measures for patients with COVID-19 and happy hypoxemia; we believe readers should be alerted to problems with the authors' interpretations and recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.