ArticleBMC psychiatry2020
Major depressive disorder and its association with adherence to antiretroviral therapy and quality of life: cross-sectional survey of people living with HIV/AIDS in Northwest Ethiopia.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Depressive symptoms and its determinants among people living with HIV in Africa: systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Exploring optimal HAART adherence rates in Ethiopian adults: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.BMJ open · 2021Pooled it
- Impact of Community Support Workers in Rural Ethiopia on Emotional and Psychosocial Health of Persons Living with HIV: Results of a Three-Year Randomized Community Trial.AIDS and behavior · 2023Trial
- Correlates of internalized stigma and antiretroviral therapy adherence among people living with HIV in the Volta region of Ghana.BMC public health · 2025Article
- Depression and the revolving door of HIV care: using multistate approaches to understand complex longitudinal exposure/outcome relationships among a cohort of people entering HIV care in Cameroon from 2019 to 2020.BMJ public health · 2025Article
- Quality of Life in People With HIV at the End of Life: Preliminary Results From the Last Gift Observational Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2025Observational
- Mental health and its consequences in people living with HIV: A network approach.Brain and behavior · 2024Article
- The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men.Biosafety and health · 2024Article
- Process evaluation of the HIV+D intervention for integrating the management of depression in routine HIV care in Uganda.PLOS mental health · 2024Article
- Interaction of social support and depressive symptoms on antiretroviral therapy adherence among people living with HIV in South Africa.Health SA = SA Gesondheid · 2024Article
- Substance Use and Depression Impede ART Adherence Among Female Sex Workers Living with HIV in the Dominican Republic.AIDS and behavior · 2023Article
- 'They should show them love even if their status of being HIV positive is known': Youth and caregiver stigma experience and strategies to end HIV stigma in schools.Tropical medicine & international health : TM & IH · 2023Article
- High Psychosocial Burden Relates to Poorer Antiretroviral Treatment Adherence Among Black/African American People with HIV.AIDS patient care and STDs · 2023Article
- Prevalence, severity, and associated factors of depression in newly diagnosed people living with HIV in Kilimanjaro, Tanzania: a cross-sectional study.BMC psychiatry · 2023Article
- Prevalence of suicidality in clinically stable patients with major depressive disorder during the COVID-19 pandemic.Journal of affective disorders · 2022Observational
- Exploring the barriers to the antiretroviral therapy adherence among people living with HIV in Bangladesh: A qualitative approach.PloS one · 2022Article
- Acceptability and feasibility of peer-administered group interpersonal therapy for depression for people living with HIV/AIDS-a pilot study in Northwest Ethiopia.Pilot and feasibility studies · 2021Article
- Depression, Medication Adherence, and Beliefs as Determinants of Health-Related Quality of Life among People Living with HIV: A Cross-Sectional Pharmacoepidemiologic Study in Indonesia.Journal of the International Association of Providers of AIDS CareArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundMajor depression is believed to affect treatment adherence and overall quality of life (QoL) of people living with HIV/AIDS (PLWHA). Comorbid major depression contributes to a two-fold higher risk of mortality among PLWHA. Understanding the relationships of major depression, adherence to antiretroviral therapy (ART) and QoL is important to identify areas for intervention. The aim of this study is to examine relationship of major depressive disorder (MDD) and adherence to ART with QoL, and to investigate socio-demographic and clinical factors associated with MDD, adherence and QoL among PLWHA in Northwest Ethiopia.
methodA cross-sectional study was conducted in the ART clinic of Felege-Hiwot referral hospital in Northwest Ethiopia from July to October 2019. Adult PLWHA were selected using a systematic random sampling technique. Data were collected using interview administered questionnaires and chart reviews. Mini International Neuropsychiatric Interview and WHOQOL-HIV-BREF-Eth instruments were used to measure MDD and QoL respectively. Adherence to ART was assessed using pill count data from patients' adherence monitoring chart. Univariate and multivariate Poisson regressions were used to assess associations of socio-demographic and clinical factors with MDD and adherence to ART. A multivariate linear regression was used to examine the associations of both MDD and adherence with overall QoL.
resultOf the total of 393 invited participants, 391 (99.5%) completed the interviews. MDD was negatively associated with overall QoL: participants with MDD had a lower QoL score of 0.17 points compared to those with no MDD. MDD was associated with reduced adherence to ART when functional disability was controlled (RR = 1.43; 95%CI = 1.05, 1.96; p = 0.025). However, there was no statistical association between adherence to ART and overall QoL. Functional disability was associated with both MDD (RR = 5.07; 95%CI = 3.27,7.86; p < 0.001) and overall QoL (β = 0.29; 95%CI = 0.21,0.36; p < 0.001).
conclusionThe relationship between MDD and QoL indicates the need for feasible, acceptable and evidence-based mental health interventions to reduce depression and improve overall QoL of PLWHA. We recommend future studies investigate causal relationships of MDD, adherence to ART and QoL of PLWHA to better understand priority areas for intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.