Evidence map›Paper›PMID 32972302›Full record

ArticleAutophagy2021

TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the

Cefan Zhou, Yanyan Liang, Li Zhou, Yanan Yan, Nanxi Liu, Rui Zhang, Yuan Huang, Ming Wang, Yongfei Tang, Declan William Ali and 4 more

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
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  14. The mechanisms and clinical significance of CD8Cancer biology & medicine · 2025
    Review
  15. Article
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  18. Article
  19. The role of AMPK in pancreatic cancer: from carcinogenesis to treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Cefan ZhouNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.ORCID 0000-0003-0680-3843
Yanyan LiangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
Li ZhouAnimal Biosafety Level III Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan, China.ORCID 0000-0002-6736-0057
Yanan YanNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
Nanxi LiuNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
Rui ZhangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
Yuan HuangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.
Ming WangDepartment of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.ORCID 0000-0002-2836-1217
Yongfei TangDepartment of Pathology, Renmin Hospital of Wuhan University, Wuhan, China.
Declan William AliDepartment of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
Yefu WangThe State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.
Marek MichalakDepartment of Biochemistry, University of Alberta, Edmonton, AB, Canada.ORCID 0000-0002-9343-9084
Xing-Zhen ChenMembrane Protein Disease Research Group, Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Jingfeng TangNational "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan, China.ORCID 0000-0002-5524-4518
Hubei University of Technology · CNUniversity of Alberta · CAWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is one of the most aggressive tumors associated with a poor clinical prognosis, weakly effective therapeutic options. Therefore, there is a strong impetus to discover new therapeutic targets in pancreatic cancer. In the present study, we first demonstrated that TSPAN1 is upregulated in pancreatic cancer and that TSPAN1 depletion decreases pancreatic cancer cell proliferation

Indexed as

AutophagyMicroRNAsNeoplasm ProteinsPancreatic NeoplasmsWnt Signaling PathwayAnimalsbeta CateninHumansTetraspaninsZebrafishbeta CateninCTNNB1 protein, humanFAM83A protein, humanMicroRNAsMIRN454 microRNA, humanNeoplasm ProteinsTetraspaninsTSPAN1 protein, humanAutophagyFAM83AMIR454pancreatic cancertetraspanin 1WNT-CTNNB1

Identifiers

PMID32972302
PMCPMC8525961
OpenAlexW3089178425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.