Evidence map›Paper›PMID 32972274›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2022

Maternal-fetal genetic interactions, imprinting, and risk of placental abruption.

Tsegaselassie Workalemahu, Daniel A Enquobahrie, Bizu Gelaye, Mahlet G Tadesse, Sixto E Sanchez, Fasil Tekola-Ayele, Anjum Hajat, Timothy A Thornton, Cande V Ananth, Michelle A Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Tsegaselassie WorkalemahuDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4571-9740
Daniel A EnquobahrieDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Bizu GelayeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mahlet G TadesseDepartment of Mathematics and Statistics, Georgetown University, Washington, DC, USA.
Sixto E SanchezFacultad de Medicina Humana, Universidad de San Martín de Porres, Lima, Peru.
Fasil Tekola-AyeleDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
Anjum HajatDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Timothy A ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Cande V AnanthDivision of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Michelle A WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
University of Washington · USHarvard University · USGeorgetown University · USRutgers, The State University of New Jersey · USUniversidad de San Martín de Porres · PEUniversity of Utah · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Vascular Health and Risk Factors in Children with Down SyndromeKL2TR002539 · NCATS · UNIVERSITY OF UTAH · PI MURTAUGH, MAUREEN A, NYGAARD, INGRID E · 2018 to 2022
$4.3M
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic PlacentalR01HD059827 · NICHD · SWEDISH MEDICAL CENTER, FIRST HILL · PI ANANTH, CANDE V., WILLIAMS, MICHELLE A. · 2010 to 2014
$2.7M
NCATS NIH HHS KL2 TR002539NICHD NIH HHS R01 HD059827NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

resultsAbruption cases were more likely to experience preeclampsia, have shorter gestational age, and deliver infants with lower birthweight compared with controls. Models with MFGI effects provided improved fit than models with only maternal and fetal genotype main effects for SNP rs12530904 (

conclusionsWe identified novel PA-related maternal-fetal MB gene interactions and imprinting effects that highlight the role of the fetus in PA risk development. Findings can inform mechanistic investigations to understand the pathogenesis of PA.

Indexed as

Abruptio PlacentaeGenomic ImprintingFemaleFetusHumansPlacentaPolymorphism, Single NucleotidePregnancyfetalgenetic interactionsGenetic variationimprintingmaternal

Identifiers

PMID32972274
PMCPMC8601203
OpenAlexW3088763696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.