Evidence map›Paper›PMID 32972270›Full record

ArticleRenal failure2020

Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.

Xiangjun Zhou, Yongwei Li, Cheng Wu, Weimin Yu, Fan Cheng

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xiangjun ZhouDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Yongwei LiDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Cheng WuDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Weimin YuDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, China.
Fan ChengDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0001-6684-1433
Wuhan University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia-reperfusion injury is a leading cause of acute kidney injury, but its underlying mechanism remains poorly understood and effective therapies are still lacking. Here, we identified lncRNA XLOC_032768 as a novel target in renal ischemia-reperfusion injury by analyzing differentially expressed genes of the transcriptome data. PCR results show that XLOC_032768 was markedly downregulated in the kidney during renal ischemia-reperfusion in mice and in cultured kidney cells during hypoxia. Upon induction

Indexed as

Acute Kidney InjuryAnimalsApoptosisCell LineEpithelial CellsFibronectinsHumansMaleMiceMice, Inbred C57BLProtective AgentsReperfusion InjuryRNA, Long NoncodingSignal TransductionTransforming Growth Factor beta1FibronectinsFNDC3B protein, humanProtective AgentsRNA, Long NoncodingTGFB1 protein, humanTransforming Growth Factor beta1Acute renal injurycell deathhypoxiaischemia-reperfusionlncRNA

Identifiers

PMID32972270
PMCPMC7534267
OpenAlexW3088564985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.