Evidence map›Paper›PMID 32972200›Full record

ArticleThe American journal of psychiatry2020

Association of Prenatal Alcohol Exposure With Psychological, Behavioral, and Neurodevelopmental Outcomes in Children From the Adolescent Brain Cognitive Development Study.

Briana Lees, Louise Mewton, Joanna Jacobus, Emilio A Valadez, Lexine A Stapinski, Maree Teesson, Susan F Tapert, Lindsay M Squeglia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
29.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 173 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Briana LeesThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Louise MewtonThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Joanna JacobusThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Emilio A ValadezThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Lexine A StapinskiThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Maree TeessonThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Susan F TapertThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
Lindsay M SquegliaThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Camperdown, Australia (Lees, Stapinski, Teesson); Centre for Healthy Brain Ageing, University of New South Wales, Randwick, Australia (Mewton); Department of Psychiatry, University of California, San Diego, La Jolla (Jacobus, Tapert); Department of Human Development and Quantitative Methodology, University of Maryland, College Park (Valadez); Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston (Squeglia).
The University of Sydney · AU

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
NIAAA NIH HHS K23 AA025399NIAAA NIH HHS R01 AA027399NIDA NIH HHS R21 DA047953NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

objectiveData on the neurodevelopmental and associated behavioral effects of light to moderate in utero alcohol exposure are limited. This retrospective investigation tested for associations between reported maternal prenatal alcohol use and psychological, behavioral, and neurodevelopmental outcomes in substance-naive youths.

methodsParticipants were 9,719 youths (ages 9.0 to 10.9 years) from the Adolescent Brain Cognitive Development Study. Based on parental reports, 2,518 (25.9%) had been exposed to alcohol in utero. Generalized additive mixed models and multilevel cross-sectional and longitudinal mediation models were used to test whether prenatal alcohol exposure was associated with psychological, behavioral, and cognitive outcomes, and whether differences in brain structure and resting-state functional connectivity partially explained these associations at baseline and 1-year follow-up, after controlling for possible confounding factors.

resultsPrenatal alcohol exposure of any severity was associated with greater psychopathology, attention deficits, and impulsiveness, with some effects showing a dose-dependent response. Children with prenatal alcohol exposure, compared with those without, displayed greater cerebral and regional volume and greater regional surface area. Resting-state functional connectivity was largely unaltered in children with in utero exposure. Some of the psychological and behavioral outcomes at baseline and at the 1-year follow-up were partially explained by differences in brain structure among youths who had been exposed to alcohol in utero.

conclusionsAny alcohol use during pregnancy is associated with subtle yet significant psychological and behavioral effects in children. Women should continue to be advised to abstain from alcohol consumption from conception throughout pregnancy.

Indexed as

AdultBrainCase-Control StudiesChildChild BehaviorChild DevelopmentCognitionDose-Response Relationship, DrugEthanolFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingNeuropsychological TestsPregnancyEthanolBrain DevelopmentChild/Adolescent PsychiatryPrenatal Alcohol ExposurePsychopathology

Identifiers

PMID32972200
PMCPMC7924902
OpenAlexW3088793929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.