Evidence map›Paper›PMID 32971944›Full record

ArticleInternational journal of molecular sciences2020

4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model.

Chia-Hsin Wu, Ching-Huei Ou, I-Chuan Yen, Shih-Yu Lee

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Autophagy-related mechanisms for treatment of multiple myeloma.Cancer drug resistance (Alhambra, Calif.) · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Role of Apoptosis in Wound Healing and Apoptosis Alterations in Microgravity.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chia-Hsin WuGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-8389-6599
Ching-Huei OuDepartment of Anesthesiology, Cheng-Hsin General Hospital, Taipei 11220, Taiwan.
I-Chuan YenSchool of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0003-3673-9870
Shih-Yu LeeGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-4713-6410
National Defense Medical Center · TWCheng Hsin General Hospital · TW

Funding

Cheng Hsin General Hospital Foundation CH-NDMC-108-1Ministry of Science and Technology 108-2320-B-016-008-MY3
6 · The paper itself

Abstract

Astronauts suffer from 1-2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from

Indexed as

Weightlessness Simulation4-ButyrolactoneAnimalsApoptosisAutophagyCell Cycle CheckpointsCyclohexanonesGene Expression RegulationMiceOsteoclastsRAW 264.7 CellsSignal Transduction4-acetylantroquinonol B4-ButyrolactoneCyclohexanones4-acetylantroquinonol Bautophagymicrogravityosteoclastogenesis

Identifiers

PMID32971944
PMCPMC7555662
OpenAlexW3087973788

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.