Evidence map›Paper›PMID 32971865›Full record

ReviewBiomolecules2020

Arsenic Methyltransferase and Methylation of Inorganic Arsenic.

Nirmal K Roy, Anthony Murphy, Max Costa

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 62 citations in OpenAlex.

  1. Genome-based identification of heavy metal resistance-associated genes in Bacillus enclensis ABF750 isolated from the polluted sediment of Versova Creek.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Persistent effects of early-life arsenic exposure inEnvironmental science. Processes & impacts · 2026
    Article
  7. Review
  8. Article
  9. Assessing the Impact of PMEnvironmental science & technology · 2024
    Article
  10. Article
  11. Review
  12. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
    Article
  13. Arsenic and Tau Phosphorylation: a Mechanistic Review.Biological trace element research · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nirmal K RoyDepartment of Environmental Medicine, NYU School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Anthony MurphyDepartment of Environmental Medicine, NYU School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Max CostaDepartment of Environmental Medicine, NYU School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
New York University · US

Funding

RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
SATB2 and Nickel CarcingenesisR01ES022935 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 2014 to 2018
$2.1M
Epigenetic Dysregulation by Oxidative Stress from Environmental InsultsR01ES023174 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX, CUDDAPAH, SURESH · 2013 to 2016
$2.0M
NIEHS NIH HHS P30 ES000260NIEHS NIH HHS R01 ES022935NIH HHS ES026138
6 · The paper itself

Abstract

Arsenic occurs naturally in the environment, and exists predominantly as inorganic arsenite (As (III) and arsenate As (V)). Arsenic contamination of drinking water has long been recognized as a major global health concern. Arsenic exposure causes changes in skin color and lesions, and more severe health conditions such as black foot disease as well as various cancers originating in the lungs, skin, and bladder. In order to efficiently metabolize and excrete arsenic, it is methylated to monomethylarsonic and dimethylarsinic acid. One single enzyme, arsenic methyltransferase (AS3MT) is responsible for generating both metabolites. AS3MT has been purified from several mammalian and nonmammalian species, and its mRNA sequences were determined from amino acid sequences. With the advent of genome technology, mRNA sequences of

Indexed as

AnimalsArsenicCysteineHumansMethylationMethyltransferasesPhylogenyPolymorphism, Single NucleotideWater Pollutants, ChemicalArsenicAS3MT protein, humanCysteineMethyltransferasesWater Pollutants, Chemicalbiotransformationcarcinogensmetals

Identifiers

PMID32971865
PMCPMC7563989
OpenAlexW3088205486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.