Evidence map›Paper›PMID 32971824›Full record

ArticleInternational journal of molecular sciences2020

A Safe and Multitasking Antimicrobial Decapeptide: The Road from De Novo Design to Structural and Functional Characterization.

Bruna Agrillo, Yolande T R Proroga, Marta Gogliettino, Marco Balestrieri, Rosarita Tatè, Luigi Nicolais, Gianna Palmieri

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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  6. Creation of New Antimicrobial Peptides.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Bruna AgrilloMaterias Srl, 80146 Naples, Italy.
Yolande T R ProrogaDepartment of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Portici, Italy.
Marta GogliettinoInstitute of Biosciences and BioResources, National Research Council (IBBR-CNR), 80131 Napoli, Italy.
Marco BalestrieriInstitute of Biosciences and BioResources, National Research Council (IBBR-CNR), 80131 Napoli, Italy.ORCID 0000-0003-4343-2148
Rosarita TatèInstitute of Genetics and Biophysics, National Research Council (IGB-CNR), 80131 Naples, Italy.
Luigi NicolaisMaterias Srl, 80146 Naples, Italy.
Gianna PalmieriInstitute of Biosciences and BioResources, National Research Council (IBBR-CNR), 80131 Napoli, Italy.ORCID 0000-0002-9007-4075
Institute of Biosciences and Bioresources · ITStazione Sperimentale per l'Industria delle Pelli e delle Materie Concianti · ITInstitute of Genetics and Biophysics · ITIstituto Zooprofilattico Sperimentale del Mezzogiorno · IT

Funding

Ministero della Salute Ricerca Corrente 2018-IZS ME 06/18 RCRegione Campania B63D18000530007Regione Campania POR FESR CAMPANIA 2014/2020
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are excellent candidates to fight multi-resistant pathogens worldwide and are considered promising bio-preservatives to control microbial spoilage through food processing. To date, designing de novo AMPs with high therapeutic indexes, low-cost synthesis, high resistance, and bioavailability, remains a challenge. In this study, a novel decapeptide, named RiLK1, was rationally designed starting from the sequence of the previously characterized AMP 1018-K6, with the aim of developing short peptides, and promoting higher selectivity over mammalian cells, antibacterial activity, and structural resistance under different salt, pH, and temperature conditions. Interestingly, RiLK1 displayed a broad-spectrum of bactericidal activity against Gram-positive and Gram-negative bacteria, including multidrug resistant clinical isolates of

Indexed as

Anti-Bacterial AgentsOligopeptidesPore Forming Cytotoxic ProteinsFibroblastsHumansKeratinocytesSalmonellaStructure-Activity RelationshipAnti-Bacterial AgentsOligopeptidesPore Forming Cytotoxic Proteinsantifungal activityantimicrobial peptidefood packagingfood pathogensMDR Salmonella spp.

Identifiers

PMID32971824
PMCPMC7555028
OpenAlexW3088251439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.